MIR5587

Summary

MIR5587 (microRNA 5587, HGNC:43508) is a microRNA gene on chromosome 16p13.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847028 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43508
Approved symbol	MIR5587
Name	microRNA 5587
Location	16p13.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5587
Ensembl gene	ENSG00000266124
Ensembl biotype	miRNA
Entrez	100847028
RNAcentral	URS000075A780 — miRNA, 53 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581803

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581803 — 1 exons

Exon	Start	End
ENSE00002699902	535316	535368

Expression profiles

Bgee: expression breadth ubiquitous, 110 present calls, max score 92.02.

Top tissues by expression

110 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	92.02	gold quality
skeletal muscle tissue	UBERON:0001134	91.69	gold quality
adrenal tissue	UBERON:0018303	88.29	gold quality
endometrium	UBERON:0001295	86.99	gold quality
metanephros cortex	UBERON:0010533	86.51	gold quality
bone marrow	UBERON:0002371	83.87	gold quality
duodenum	UBERON:0002114	83.53	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.26	gold quality
blood	UBERON:0000178	82.30	gold quality
cerebellar hemisphere	UBERON:0002245	81.98	gold quality
pancreas	UBERON:0001264	81.28	gold quality
vermiform appendix	UBERON:0001154	81.22	gold quality
kidney	UBERON:0002113	81.21	gold quality
transverse colon	UBERON:0001157	81.19	gold quality
body of pancreas	UBERON:0001150	81.09	gold quality
small intestine	UBERON:0002108	80.67	gold quality
small intestine Peyer’s patch	UBERON:0003454	80.41	gold quality
rectum	UBERON:0001052	80.12	gold quality
muscle of leg	UBERON:0001383	79.92	gold quality
stomach	UBERON:0000945	79.81	gold quality
lymph node	UBERON:0000029	79.75	gold quality
adult mammalian kidney	UBERON:0000082	79.68	gold quality
body of stomach	UBERON:0001161	79.43	gold quality
smooth muscle tissue	UBERON:0001135	79.25	gold quality
intestine	UBERON:0000160	79.15	gold quality
gastrocnemius	UBERON:0001388	79.12	gold quality
colon	UBERON:0001155	78.46	gold quality
lower esophagus mucosa	UBERON:0035834	78.35	gold quality
right atrium auricular region	UBERON:0006631	78.22	gold quality
fundus of stomach	UBERON:0001160	78.01	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• WNT5B exerts oncogenic effects and is negatively regulated by miR-5587-3p in lung adenocarcinoma progression. (PMID:31666682)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.