MIR5588

Summary

MIR5588 (microRNA 5588, HGNC:43505) is a microRNA gene on chromosome 3q27.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847054 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43505
Approved symbol	MIR5588
Name	microRNA 5588
Location	3q27.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5588
Ensembl gene	ENSG00000264614
Ensembl biotype	miRNA
Entrez	100847054
RNAcentral	URS0000759BED — miRNA, 63 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581890

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581890 — 1 exons

Exon	Start	End
ENSE00002692818	185253210	185253272

Expression profiles

Bgee: expression breadth broad, 49 present calls, max score 88.54.

Top tissues by expression

49 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	88.54	gold quality
monocyte	CL:0000576	76.51	gold quality
blood	UBERON:0000178	76.01	gold quality
heart	UBERON:0000948	75.16	gold quality
endometrium	UBERON:0001295	74.30	gold quality
liver	UBERON:0002107	73.26	gold quality
body of pancreas	UBERON:0001150	71.49	gold quality
stomach	UBERON:0000945	71.31	gold quality
right lobe of liver	UBERON:0001114	71.23	gold quality
adult mammalian kidney	UBERON:0000082	70.96	gold quality
heart left ventricle	UBERON:0002084	70.33	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.92	gold quality
lung	UBERON:0002048	69.42	gold quality
body of stomach	UBERON:0001161	69.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.54	gold quality
esophagus	UBERON:0001043	67.11	gold quality
adipose tissue	UBERON:0001013	67.10	gold quality
Ammon’s horn	UBERON:0001954	66.89	gold quality
anterior cingulate cortex	UBERON:0009835	66.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.04	gold quality
left lobe of thyroid gland	UBERON:0001120	65.99	gold quality
ascending aorta	UBERON:0001496	65.97	gold quality
esophagus mucosa	UBERON:0002469	65.81	gold quality
omental fat pad	UBERON:0010414	65.50	gold quality
multicellular organism	UBERON:0000468	65.42	gold quality
pituitary gland	UBERON:0000007	65.04	gold quality
transverse colon	UBERON:0001157	64.96	gold quality
minor salivary gland	UBERON:0001830	64.91	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.62	gold quality
left ovary	UBERON:0002119	64.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.