MIR5589

Summary

MIR5589 (microRNA 5589, HGNC:43514) is a microRNA gene on chromosome 19p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847093 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43514
Approved symbol	MIR5589
Name	microRNA 5589
Location	19p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5589
Ensembl gene	ENSG00000266204
Ensembl biotype	miRNA
Entrez	100847093
RNAcentral	URS000075D4F5 — ncRNA, 60 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579442

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579442 — 1 exons

Exon	Start	End
ENSE00002731570	10038354	10038413

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 75.19.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	75.19	gold quality
liver	UBERON:0002107	74.70	gold quality
right lobe of liver	UBERON:0001114	72.65	gold quality
multicellular organism	UBERON:0000468	65.55	gold quality
nucleus accumbens	UBERON:0001882	65.35	gold quality
anterior cingulate cortex	UBERON:0009835	58.34	gold quality
left testis	UBERON:0004533	52.25	gold quality
right testis	UBERON:0004534	44.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.