MIR559

Summary

MIR559 (microRNA 559, HGNC:32815) is a microRNA gene on chromosome 2p21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693144 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32815
Approved symbol	MIR559
Name	microRNA 559
Location	2p21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-559
Ensembl gene	ENSG00000207923
Ensembl biotype	miRNA
Entrez	693144
RNAcentral	URS000075B15D — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385188

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385188 — 1 exons

Exon	Start	End
ENSE00001500194	47377675	47377770

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 91.32.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	91.32	gold quality
transverse colon	UBERON:0001157	90.28	gold quality
endometrium	UBERON:0001295	89.50	gold quality
small intestine	UBERON:0002108	88.68	gold quality
small intestine Peyer’s patch	UBERON:0003454	88.25	gold quality
intestine	UBERON:0000160	87.88	gold quality
colon	UBERON:0001155	87.50	gold quality
rectum	UBERON:0001052	85.70	gold quality
mucosa of transverse colon	UBERON:0004991	85.08	gold quality
heart	UBERON:0000948	84.64	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.09	gold quality
body of pancreas	UBERON:0001150	80.66	gold quality
vermiform appendix	UBERON:0001154	80.17	gold quality
body of stomach	UBERON:0001161	78.94	gold quality
stomach	UBERON:0000945	78.44	gold quality
fundus of stomach	UBERON:0001160	78.34	gold quality
right lobe of thyroid gland	UBERON:0001119	78.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	78.03	gold quality
heart left ventricle	UBERON:0002084	77.99	gold quality
left lobe of thyroid gland	UBERON:0001120	76.44	gold quality
thyroid gland	UBERON:0002046	76.02	gold quality
endocervix	UBERON:0000458	75.70	gold quality
placenta	UBERON:0001987	75.50	gold quality
islet of Langerhans	UBERON:0000006	75.36	gold quality
gastrocnemius	UBERON:0001388	75.21	gold quality
kidney	UBERON:0002113	74.02	gold quality
adult mammalian kidney	UBERON:0000082	73.43	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	72.68	gold quality
adrenal tissue	UBERON:0018303	72.22	gold quality
pituitary gland	UBERON:0000007	71.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• these results validate the role of miR-548d-3p and miR-559 in regulating the ERBB2 expression. (PMID:19486885)
• miR-559 polymorphism rs58450758 is linked to breast cancer. (PMID:31642395)
• Proliferation and migration of hepatocellular carcinoma are accelerated by LINC01287 via the miR-559/TCF12 axis. (PMID:32572916)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.