MIR5590

Summary

MIR5590 (microRNA 5590, HGNC:43541) is a microRNA gene on chromosome 2q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847069 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43541
Approved symbol	MIR5590
Name	microRNA 5590
Location	2q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5590
Ensembl gene	ENSG00000263783
Ensembl biotype	miRNA
Entrez	100847069
RNAcentral	URS0000759C72 — ncRNA, 54 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577826

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577826 — 1 exons

Exon	Start	End
ENSE00002699625	134857820	134857873

Expression profiles

Bgee: expression breadth broad, 40 present calls, max score 86.80.

Top tissues by expression

40 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	86.80	gold quality
calcaneal tendon	UBERON:0003701	84.80	gold quality
leukocyte	CL:0000738	78.67	gold quality
monocyte	CL:0000576	78.64	gold quality
urinary bladder	UBERON:0001255	75.40	gold quality
right lobe of liver	UBERON:0001114	73.68	gold quality
endometrium	UBERON:0001295	70.79	gold quality
muscle layer of sigmoid colon	UBERON:0035805	70.64	gold quality
lung	UBERON:0002048	70.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.54	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.92	gold quality
body of stomach	UBERON:0001161	69.85	gold quality
cerebellar hemisphere	UBERON:0002245	69.11	gold quality
right frontal lobe	UBERON:0002810	68.55	gold quality
gastrocnemius	UBERON:0001388	68.28	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.90	gold quality
body of pancreas	UBERON:0001150	67.68	gold quality
tibial artery	UBERON:0007610	67.18	gold quality
amygdala	UBERON:0001876	67.15	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.90	gold quality
skin of abdomen	UBERON:0001416	66.82	gold quality
left uterine tube	UBERON:0001303	66.35	gold quality
omental fat pad	UBERON:0010414	65.99	gold quality
thoracic mammary gland	UBERON:0005200	65.42	gold quality
esophagus mucosa	UBERON:0002469	65.37	gold quality
spleen	UBERON:0002106	65.22	gold quality
left ovary	UBERON:0002119	65.18	gold quality
right ovary	UBERON:0002118	65.11	gold quality
prostate gland	UBERON:0002367	65.04	gold quality
tibial nerve	UBERON:0001323	65.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• data introduces hsa-miR-5590-3p as a negative regulator of the TGFbeta/SMAD signaling pathway which acts through downregulation of TGFbeta-R1, TGFbeta-R2, SMAD3 and SMAD4 transcripts; therefore, it can be tested as a therapy target in cancers in which the TGFbeta/SMAD pathway is deregulated (PMID:30391930)
• SOX9-AS1 aggravates Hepatocellular carcinoma (HCC) progression and metastasis in vitro and in vivo. We demonstrated that SOX9-AS1 sponges miR-5590-3p to elevate SOX9 expression, and that SOX9 in turn transcriptionally activates SOX9-AS1. (PMID:31402556)
• Long noncoding RNA SNHG14 promotes malignancy of prostate cancer by regulating with miR-5590-3p/YY1 axis. (PMID:32432733)
• LncRNA FGD5-AS1/miR-5590-3p axis facilitates the proliferation and metastasis of renal cell carcinoma through ERK/AKT signalling. (PMID:32964964)
• MiR-5590-3p inhibits the proliferation and invasion of ovarian cancer cells through mediating the Wnt/beta-catenin signaling pathway by targeting TNIK. (PMID:37318197)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.