MIR5591

Summary

MIR5591 (microRNA 5591, HGNC:43531) is a microRNA gene on chromosome 4p14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847065 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43531
Approved symbol	MIR5591
Name	microRNA 5591
Location	4p14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5591
Ensembl gene	ENSG00000264621
Ensembl biotype	miRNA
Entrez	100847065
RNAcentral	URS000075CE05 — ncRNA, 65 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578248

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578248 — 1 exons

Exon	Start	End
ENSE00002724098	39411910	39411974

Expression profiles

Bgee: expression breadth tissue_specific, 6 present calls, max score 73.12.

Top tissues by expression

6 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	73.12	gold quality
body of pancreas	UBERON:0001150	70.50	gold quality
omental fat pad	UBERON:0010414	67.52	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.65	gold quality
right frontal lobe	UBERON:0002810	62.46	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• these results indicated that miR-5591-5p targeting AGEs/AGER/JNK signaling axis possibly regulates the effect of ADSCs in repairing diabetic wound. (PMID:29752466)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.