MIR561

Summary

MIR561 (microRNA 561, HGNC:32817) is a microRNA gene on chromosome 2q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693146 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32817
Approved symbol	MIR561
Name	microRNA 561
Location	2q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-561
Ensembl gene	ENSG00000207951
Ensembl biotype	miRNA
Entrez	693146
RNAcentral	URS000075C677 — miRNA, 97 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385216

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385216 — 1 exons

Exon	Start	End
ENSE00001500222	188297492	188297588

Expression profiles

Bgee: expression breadth broad, 77 present calls, max score 84.51.

Top tissues by expression

77 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	84.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	84.38	gold quality
adrenal tissue	UBERON:0018303	84.18	gold quality
blood	UBERON:0000178	80.62	gold quality
muscle of leg	UBERON:0001383	78.25	gold quality
kidney	UBERON:0002113	77.65	gold quality
stomach	UBERON:0000945	76.12	gold quality
body of uterus	UBERON:0009853	75.52	gold quality
heart left ventricle	UBERON:0002084	75.35	gold quality
endometrium	UBERON:0001295	73.33	gold quality
body of pancreas	UBERON:0001150	72.37	gold quality
heart	UBERON:0000948	72.26	gold quality
body of stomach	UBERON:0001161	72.01	gold quality
left adrenal gland cortex	UBERON:0035825	71.69	gold quality
islet of Langerhans	UBERON:0000006	71.33	gold quality
gastrocnemius	UBERON:0001388	71.15	gold quality
left coronary artery	UBERON:0001626	70.37	gold quality
intestine	UBERON:0000160	69.91	gold quality
colon	UBERON:0001155	69.23	gold quality
prostate gland	UBERON:0002367	69.20	gold quality
putamen	UBERON:0001874	68.36	gold quality
placenta	UBERON:0001987	68.33	gold quality
thoracic aorta	UBERON:0001515	68.09	gold quality
left adrenal gland	UBERON:0001234	67.96	gold quality
ascending aorta	UBERON:0001496	67.91	gold quality
transverse colon	UBERON:0001157	67.83	gold quality
myometrium	UBERON:0001296	67.83	gold quality
cerebellar hemisphere	UBERON:0002245	67.62	gold quality
right frontal lobe	UBERON:0002810	67.59	gold quality
ectocervix	UBERON:0012249	67.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 7)

• The rs16430 variant of thymidylate synthetase was predicted to influence the binding activity of miR-561. (PMID:24166930)
• The expression of hsa_circ_0002468 was increased during SH-SY5Y differentiation and was inversely correlated with miR-561 expression. Using qRT-PCR analysis, we showed that hsa_circ_0002468 negatively regulated miR-561 in SH-SY5Y cells. Intriguingly, the overexpression of hsa_circ_0002468 increased SH-SY5Y differentiation and reduced SH-SY5Y proliferation. (PMID:30951518)
• The miR-561-5p/CX3CL1 Signaling Axis Regulates Pulmonary Metastasis in Hepatocellular Carcinoma Involving CX3CR1(+) Natural Killer Cells Infiltration. (PMID:31367257)
• MicroRNA-561 Affects Proliferation and Cell Cycle Transition Through PTEN/AKT Signaling Pathway by Targeting P-REX2a in NSCLC. (PMID:31711559)
• Circular RNA circHIPK3 Activates Macrophage NLRP3 Inflammasome and TLR4 Pathway in Gouty Arthritis via Sponging miR-561 and miR-192. (PMID:34085163)
• MicroRNA-561-5p Inhibits Cell Proliferation and Invasion by Targeting RAC1 in Pancreatic Ductal Adenocarcinoma. (PMID:35414500)
• NBR2/miR-561-5p/DLC1 axis inhibited the development of multiple myeloma by activating the AMPK/mTOR pathway to repress glycolysis. (PMID:35951458)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.