MIR562

Summary

MIR562 (microRNA 562, HGNC:32818) is a microRNA gene on chromosome 2q37.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693147 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32818
Approved symbol	MIR562
Name	microRNA 562
Location	2q37.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-562
Ensembl gene	ENSG00000207626
Ensembl biotype	miRNA
Entrez	693147
RNAcentral	URS000075A7C1 — miRNA, 95 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384894

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384894 — 1 exons

Exon	Start	End
ENSE00001499901	232172653	232172747

Expression profiles

Bgee: expression breadth broad, 50 present calls, max score 82.49.

Top tissues by expression

50 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	82.49	gold quality
blood	UBERON:0000178	80.86	gold quality
adrenal tissue	UBERON:0018303	76.33	gold quality
endometrium	UBERON:0001295	76.11	gold quality
liver	UBERON:0002107	75.45	gold quality
stomach	UBERON:0000945	75.43	gold quality
kidney	UBERON:0002113	75.30	gold quality
gastrocnemius	UBERON:0001388	75.04	gold quality
calcaneal tendon	UBERON:0003701	72.97	gold quality
heart	UBERON:0000948	72.10	gold quality
body of pancreas	UBERON:0001150	71.93	gold quality
lower esophagus muscularis layer	UBERON:0035833	70.75	gold quality
intestine	UBERON:0000160	70.54	gold quality
adrenal gland	UBERON:0002369	68.55	gold quality
omental fat pad	UBERON:0010414	68.39	gold quality
colon	UBERON:0001155	67.97	gold quality
skin of leg	UBERON:0001511	67.94	gold quality
body of stomach	UBERON:0001161	67.69	gold quality
ascending aorta	UBERON:0001496	67.58	gold quality
lung	UBERON:0002048	67.53	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.22	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.94	gold quality
transverse colon	UBERON:0001157	66.73	gold quality
left adrenal gland	UBERON:0001234	66.10	gold quality
thoracic mammary gland	UBERON:0005200	65.89	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.88	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.55	gold quality
substantia nigra	UBERON:0002038	65.50	gold quality
left adrenal gland cortex	UBERON:0035825	65.33	gold quality
right lobe of thyroid gland	UBERON:0001119	65.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-562 expression is reduced in Wilms’ tumor and may contribute to tumorigenesis by deregulating target gene EYA1. (PMID:19789318)
• This data suggests that ANXA1-regulated miR26b* and miR562 may play a role in wound healing and tumor-induced endothelial cell tube formation by targeting NF-kappaB expression and point towards a potential therapeutic target for breast cancer. (PMID:25536365)
• Hsa_circ_0093741 competes with FRS2 for miR-562 binding sites to promote nephroblastoma progression. (PMID:36286392)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.