MIR563

Summary

MIR563 (microRNA 563, HGNC:32819) is a microRNA gene on chromosome 3p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693148 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32819
Approved symbol	MIR563
Name	microRNA 563
Location	3p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-563
Ensembl gene	ENSG00000207815
Ensembl biotype	miRNA
Entrez	693148
RNAcentral	URS000070CB5A — miRNA, 79 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385080

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385080 — 1 exons

Exon	Start	End
ENSE00001500086	15873771	15873849

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 91.35.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	91.35	gold quality
placenta	UBERON:0001987	86.09	gold quality
vermiform appendix	UBERON:0001154	81.56	gold quality
endometrium	UBERON:0001295	78.91	gold quality
blood	UBERON:0000178	78.40	gold quality
bone marrow	UBERON:0002371	78.00	gold quality
monocyte	CL:0000576	75.35	gold quality
kidney	UBERON:0002113	74.76	gold quality
stomach	UBERON:0000945	73.05	gold quality
calcaneal tendon	UBERON:0003701	72.72	gold quality
gastrocnemius	UBERON:0001388	72.60	gold quality
fallopian tube	UBERON:0003889	72.35	gold quality
descending thoracic aorta	UBERON:0002345	70.76	gold quality
heart left ventricle	UBERON:0002084	69.89	gold quality
heart	UBERON:0000948	69.82	gold quality
liver	UBERON:0002107	69.54	gold quality
tibial artery	UBERON:0007610	69.48	gold quality
prefrontal cortex	UBERON:0000451	69.41	gold quality
left ovary	UBERON:0002119	69.32	gold quality
body of pancreas	UBERON:0001150	68.61	gold quality
body of stomach	UBERON:0001161	68.49	gold quality
adult mammalian kidney	UBERON:0000082	68.40	gold quality
right ovary	UBERON:0002118	68.39	gold quality
right adrenal gland	UBERON:0001233	68.16	gold quality
thoracic aorta	UBERON:0001515	67.75	gold quality
ascending aorta	UBERON:0001496	67.64	gold quality
left coronary artery	UBERON:0001626	67.45	gold quality
apex of heart	UBERON:0002098	67.38	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-563 restrains cell proliferation via targeting LIN28B in human lung cancer. (PMID:31766078)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.