MIR567

Summary

MIR567 (microRNA 567, HGNC:32823) is a microRNA gene on chromosome 3q13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693152 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32823
Approved symbol	MIR567
Name	microRNA 567
Location	3q13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-567
Ensembl gene	ENSG00000207940
Ensembl biotype	miRNA
Entrez	693152
RNAcentral	URS00006CB61F — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385205

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385205 — 1 exons

Exon	Start	End
ENSE00001500211	112112801	112112898

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 81.42.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	81.42	gold quality
right lobe of liver	UBERON:0001114	79.85	gold quality
skin of abdomen	UBERON:0001416	79.36	gold quality
zone of skin	UBERON:0000014	78.69	gold quality
skin of leg	UBERON:0001511	78.30	gold quality
islet of Langerhans	UBERON:0000006	77.45	gold quality
gastrocnemius	UBERON:0001388	75.93	gold quality
adrenal tissue	UBERON:0018303	75.33	gold quality
blood	UBERON:0000178	75.27	gold quality
placenta	UBERON:0001987	75.14	gold quality
stomach	UBERON:0000945	74.96	gold quality
body of stomach	UBERON:0001161	74.68	gold quality
body of pancreas	UBERON:0001150	74.44	gold quality
left coronary artery	UBERON:0001626	72.88	gold quality
tibial artery	UBERON:0007610	72.27	gold quality
heart left ventricle	UBERON:0002084	72.26	gold quality
heart	UBERON:0000948	72.12	gold quality
endometrium	UBERON:0001295	72.03	gold quality
mucosa of transverse colon	UBERON:0004991	71.12	gold quality
right atrium auricular region	UBERON:0006631	69.34	gold quality
ascending aorta	UBERON:0001496	69.27	gold quality
thoracic aorta	UBERON:0001515	69.22	gold quality
omental fat pad	UBERON:0010414	69.09	gold quality
transverse colon	UBERON:0001157	69.06	gold quality
intestine	UBERON:0000160	68.89	gold quality
colon	UBERON:0001155	68.79	gold quality
minor salivary gland	UBERON:0001830	68.31	gold quality
granulocyte	CL:0000094	68.18	gold quality
myometrium	UBERON:0001296	68.16	gold quality
esophagus mucosa	UBERON:0002469	68.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.21

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Our results suggest a potential role of Hsa-miR-567 as a novel prognostic biomarker for BC and as regulator of KPNA4. (PMID:28000015)
• cMras was a sponge of miRNA-567 and released its direct target, PTPRG. cMras overexpression decreased miR-567 expression and subsequently increased PTPRG expression, while increased miRNA-567 expression blocked the effects induced by cMras. Moreover, PTPRG was downregulated in lung adenocarcinoma and patients with low PTPRG expression exhibited significantly poor prognosis. (PMID:31012177)
• miR-567 inhibits GC cell proliferation and enhances chemotherapeutic sensitization to 5-FU and oxaliplatin via a positive feedback loop (PMID:31078520)
• A novel circRNA, circNUP98, a potential biomarker, acted as an oncogene via the miR-567/ PRDX3 axis in renal cell carcinoma. (PMID:32729669)
• Downregulated circ_0001681 Predicts the Occurrence and Malignant Development of Lung Carcinoma via Negatively Modulating miR-567. (PMID:38182148)
• [Study on the molecular mechanism of circ_0000326 regulating the proliferation, invasion and migration of oral squamous cell carcinoma HSC3 cells by targeting miR-567]. (PMID:38494966)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.