MIR568

Summary

MIR568 (microRNA 568, HGNC:32824) is a microRNA gene on chromosome 3q13.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693153 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32824
Approved symbol	MIR568
Name	microRNA 568
Location	3q13.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-568
Ensembl gene	ENSG00000284134
Ensembl biotype	miRNA
Entrez	693153
RNAcentral	URS000075AF78 — miRNA, 95 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385036

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385036 — 1 exons

Exon	Start	End
ENSE00001500043	114316475	114316569

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 83.86.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.86	gold quality
hypothalamus	UBERON:0001898	78.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	71.58	gold quality
blood	UBERON:0000178	70.38	gold quality
anterior cingulate cortex	UBERON:0009835	68.07	gold quality
heart left ventricle	UBERON:0002084	63.80	gold quality
skin of leg	UBERON:0001511	58.88	gold quality
body of stomach	UBERON:0001161	58.61	gold quality
esophagus mucosa	UBERON:0002469	54.86	gold quality
tibial artery	UBERON:0007610	54.75	gold quality
skin of abdomen	UBERON:0001416	48.53	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• increased PBEF/NAMPT expression induced by bioactive agonists involves epigenetic regulation with hsa-miR-374a and hsa-miR-568 (PMID:24053186)
• Data indicate that nuclear factor of activated T cells 5 (NFAT5) is a direct target of miR-568. (PMID:24355664)
• Our results demonstrated a significant association between sporadic KC and hsa-mir-568 rs149509568 polymorphism, suggesting a potential role of the has-mir-568 in KC pathogenesis. (PMID:26845316)
• Hsa_circ_0097009 regulates proliferation, apoptosis, migration and invasion of hepatocellular carcinoma cells via miR-568/RNF38 axis. (PMID:36598315)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.