MIR5680

Summary

MIR5680 (microRNA 5680, HGNC:43492) is a microRNA gene on chromosome 8q22.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847001 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43492
Approved symbol	MIR5680
Name	microRNA 5680
Location	8q22.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5680
Ensembl gene	ENSG00000266756
Ensembl biotype	miRNA
Entrez	100847001
RNAcentral	URS000075D28B — ncRNA, 84 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577577

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577577 — 1 exons

Exon	Start	End
ENSE00002714255	102125432	102125515

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 81.93.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	81.93	gold quality
muscle of leg	UBERON:0001383	73.45	gold quality
gastrocnemius	UBERON:0001388	71.70	gold quality
blood	UBERON:0000178	70.75	gold quality
endometrium	UBERON:0001295	69.29	gold quality
heart left ventricle	UBERON:0002084	68.64	gold quality
tibial artery	UBERON:0007610	68.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.27	gold quality
minor salivary gland	UBERON:0001830	67.79	gold quality
right lung	UBERON:0002167	67.46	gold quality
thoracic mammary gland	UBERON:0005200	67.43	gold quality
spleen	UBERON:0002106	67.28	gold quality
left adrenal gland	UBERON:0001234	67.25	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.14	gold quality
body of stomach	UBERON:0001161	66.64	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.40	gold quality
thoracic aorta	UBERON:0001515	66.24	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.97	gold quality
body of uterus	UBERON:0009853	65.89	gold quality
anterior cingulate cortex	UBERON:0009835	65.75	gold quality
right atrium auricular region	UBERON:0006631	65.55	gold quality
ascending aorta	UBERON:0001496	65.50	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.32	gold quality
left coronary artery	UBERON:0001626	65.17	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.15	gold quality
transverse colon	UBERON:0001157	65.08	gold quality
ovary	UBERON:0000992	65.00	gold quality
intestine	UBERON:0000160	64.88	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	64.78	gold quality
lung	UBERON:0002048	64.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.21

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.