MIR5682

Summary

MIR5682 (microRNA 5682, HGNC:43477) is a microRNA gene on chromosome 3q13.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847043 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43477
Approved symbol	MIR5682
Name	microRNA 5682
Location	3q13.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5682
Ensembl gene	ENSG00000264477
Ensembl biotype	miRNA
Entrez	100847043
RNAcentral	URS000075A9DB — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584864

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584864 — 1 exons

Exon	Start	End
ENSE00002687714	121049640	121049715

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 80.94.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	80.94	gold quality
myometrium	UBERON:0001296	79.57	gold quality
islet of Langerhans	UBERON:0000006	72.46	gold quality
prefrontal cortex	UBERON:0000451	69.81	gold quality
hypothalamus	UBERON:0001898	69.24	gold quality
body of stomach	UBERON:0001161	68.60	gold quality
nucleus accumbens	UBERON:0001882	66.45	gold quality
putamen	UBERON:0001874	65.60	gold quality
esophagus mucosa	UBERON:0002469	64.44	gold quality
left adrenal gland	UBERON:0001234	64.05	gold quality
endometrium	UBERON:0001295	64.03	gold quality
anterior cingulate cortex	UBERON:0009835	63.67	gold quality
cerebellar hemisphere	UBERON:0002245	63.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.63	gold quality
right hemisphere of cerebellum	UBERON:0014890	63.60	gold quality
amygdala	UBERON:0001876	63.06	gold quality
Ammon’s horn	UBERON:0001954	62.35	gold quality
caudate nucleus	UBERON:0001873	62.30	gold quality
right frontal lobe	UBERON:0002810	61.59	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.53	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.98	gold quality
left ovary	UBERON:0002119	60.95	gold quality
Brodmann (1909) area 9	UBERON:0013540	59.58	gold quality
right lobe of thyroid gland	UBERON:0001119	59.39	gold quality
left lobe of thyroid gland	UBERON:0001120	59.30	gold quality
pituitary gland	UBERON:0000007	59.02	gold quality
thyroid gland	UBERON:0002046	58.27	gold quality
right ovary	UBERON:0002118	58.25	gold quality
prostate gland	UBERON:0002367	55.47	gold quality
corpus callosum	UBERON:0002336	46.38	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.