MIR5683

Summary

MIR5683 (microRNA 5683, HGNC:43453) is a microRNA gene on chromosome 6p25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847034 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43453
Approved symbol	MIR5683
Name	microRNA 5683
Location	6p25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5683
Ensembl gene	ENSG00000283616
Ensembl biotype	miRNA
Entrez	100847034
RNAcentral	URS000075C4DA — ncRNA, 76 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636514

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636514 — 1 exons

Exon	Start	End
ENSE00003798767	6169334	6169409

Expression profiles

Bgee: expression breadth tissue_specific, 9 present calls, max score 69.61.

Top tissues by expression

9 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
esophagogastric junction muscularis propria	UBERON:0035841	69.61	gold quality
body of stomach	UBERON:0001161	68.05	gold quality
esophagus mucosa	UBERON:0002469	65.55	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.43	gold quality
skin of abdomen	UBERON:0001416	61.89	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.62	gold quality
subcutaneous adipose tissue	UBERON:0002190	61.41	gold quality
tibial nerve	UBERON:0001323	60.55	gold quality
spleen	UBERON:0002106	55.82	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MiR-5683 suppresses glycolysis and proliferation through targeting pyruvate dehydrogenase kinase 4 in gastric cancer. (PMID:32780563)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.