MIR5684

Summary

MIR5684 (microRNA 5684, HGNC:43544) is a microRNA gene on chromosome 19p13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847071 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43544
Approved symbol	MIR5684
Name	microRNA 5684
Location	19p13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5684
Ensembl gene	ENSG00000263800
Ensembl biotype	miRNA
Entrez	100847071
RNAcentral	URS000075B768 — miRNA, 65 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585074

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585074 — 1 exons

Exon	Start	End
ENSE00002720202	12787128	12787192

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 90.65.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	90.65	gold quality
vermiform appendix	UBERON:0001154	85.92	gold quality
adrenal tissue	UBERON:0018303	85.44	gold quality
granulocyte	CL:0000094	82.53	gold quality
bone marrow	UBERON:0002371	78.94	gold quality
monocyte	CL:0000576	77.76	gold quality
blood	UBERON:0000178	76.97	gold quality
muscle of leg	UBERON:0001383	75.24	gold quality
gastrocnemius	UBERON:0001388	74.41	gold quality
body of stomach	UBERON:0001161	72.84	gold quality
adrenal gland	UBERON:0002369	72.54	gold quality
islet of Langerhans	UBERON:0000006	72.47	gold quality
lung	UBERON:0002048	71.66	gold quality
putamen	UBERON:0001874	71.34	gold quality
smooth muscle tissue	UBERON:0001135	71.29	gold quality
heart left ventricle	UBERON:0002084	71.04	gold quality
stomach	UBERON:0000945	70.91	gold quality
heart	UBERON:0000948	70.57	gold quality
right lobe of liver	UBERON:0001114	69.98	gold quality
kidney	UBERON:0002113	69.75	gold quality
left adrenal gland cortex	UBERON:0035825	69.70	gold quality
right atrium auricular region	UBERON:0006631	69.56	gold quality
left adrenal gland	UBERON:0001234	68.97	gold quality
right lung	UBERON:0002167	68.68	gold quality
body of pancreas	UBERON:0001150	68.15	gold quality
tibial artery	UBERON:0007610	68.03	gold quality
urinary bladder	UBERON:0001255	67.63	gold quality
endometrium	UBERON:0001295	67.62	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.47	gold quality
adult mammalian kidney	UBERON:0000082	67.42	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.