MIR5685

Summary

MIR5685 (microRNA 5685, HGNC:43543) is a microRNA gene on chromosome 6p12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847075 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43543
Approved symbol	MIR5685
Name	microRNA 5685
Location	6p12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5685
Ensembl gene	ENSG00000264056
Ensembl biotype	miRNA
Entrez	100847075
RNAcentral	URS000075D3B4 — miRNA, 79 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579080

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579080 — 1 exons

Exon	Start	End
ENSE00002707968	53276993	53277071

Expression profiles

Bgee: expression breadth ubiquitous, 101 present calls, max score 88.68.

Top tissues by expression

101 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	88.68	gold quality
placenta	UBERON:0001987	84.10	gold quality
thoracic mammary gland	UBERON:0005200	80.01	gold quality
blood	UBERON:0000178	78.44	gold quality
lymph node	UBERON:0000029	77.90	gold quality
granulocyte	CL:0000094	77.88	gold quality
left uterine tube	UBERON:0001303	77.88	gold quality
endocervix	UBERON:0000458	77.36	gold quality
ectocervix	UBERON:0012249	77.15	gold quality
subcutaneous adipose tissue	UBERON:0002190	76.95	gold quality
prefrontal cortex	UBERON:0000451	76.62	gold quality
adult mammalian kidney	UBERON:0000082	76.58	gold quality
monocyte	CL:0000576	76.35	gold quality
adrenal tissue	UBERON:0018303	76.17	gold quality
adipose tissue	UBERON:0001013	75.49	gold quality
muscle of leg	UBERON:0001383	75.07	gold quality
liver	UBERON:0002107	74.87	gold quality
tibial nerve	UBERON:0001323	74.78	gold quality
urinary bladder	UBERON:0001255	74.58	gold quality
gastrocnemius	UBERON:0001388	74.57	gold quality
fundus of stomach	UBERON:0001160	74.25	gold quality
upper lobe of left lung	UBERON:0008952	74.19	gold quality
lung	UBERON:0002048	74.10	gold quality
popliteal artery	UBERON:0002250	74.06	gold quality
tibial artery	UBERON:0007610	74.04	gold quality
right adrenal gland cortex	UBERON:0035827	73.93	gold quality
left coronary artery	UBERON:0001626	73.83	gold quality
prostate gland	UBERON:0002367	73.70	gold quality
omental fat pad	UBERON:0010414	73.60	gold quality
right ovary	UBERON:0002118	73.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.86

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.