MIR5688

Summary

MIR5688 (microRNA 5688, HGNC:43463) is a microRNA gene on chromosome 3p12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847077 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43463
Approved symbol	MIR5688
Name	microRNA 5688
Location	3p12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5688
Ensembl gene	ENSG00000264084
Ensembl biotype	miRNA
Entrez	100847077
RNAcentral	URS00007599C8 — miRNA, 83 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580619

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580619 — 1 exons

Exon	Start	End
ENSE00002715830	85385710	85385792

Expression profiles

Bgee: expression breadth broad, 37 present calls, max score 85.13.

Top tissues by expression

37 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	85.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.35	gold quality
tibial nerve	UBERON:0001323	77.81	gold quality
stomach	UBERON:0000945	76.85	gold quality
intestine	UBERON:0000160	75.90	gold quality
blood	UBERON:0000178	75.49	gold quality
heart left ventricle	UBERON:0002084	74.54	gold quality
esophagus mucosa	UBERON:0002469	73.14	gold quality
gastrocnemius	UBERON:0001388	71.73	gold quality
endometrium	UBERON:0001295	69.23	gold quality
right atrium auricular region	UBERON:0006631	68.31	gold quality
tibial artery	UBERON:0007610	68.07	gold quality
vagina	UBERON:0000996	66.89	gold quality
corpus callosum	UBERON:0002336	66.31	gold quality
nucleus accumbens	UBERON:0001882	66.23	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.18	gold quality
lung	UBERON:0002048	65.32	gold quality
skin of leg	UBERON:0001511	64.60	gold quality
body of uterus	UBERON:0009853	64.40	gold quality
Ammon’s horn	UBERON:0001954	63.76	gold quality
hypothalamus	UBERON:0001898	62.70	gold quality
cerebellar hemisphere	UBERON:0002245	62.67	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.55	gold quality
anterior cingulate cortex	UBERON:0009835	62.48	gold quality
omental fat pad	UBERON:0010414	62.41	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	62.40	gold quality
Brodmann (1909) area 9	UBERON:0013540	61.97	gold quality
left ovary	UBERON:0002119	61.65	gold quality
spleen	UBERON:0002106	61.48	gold quality
caudate nucleus	UBERON:0001873	61.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• miR-495 and miR-5688 are down-regulated in non-small cell lung cancer under hypoxia to maintain interleukin-11 expression. (PMID:32720740)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.