MIR5689

Summary

MIR5689 (microRNA 5689, HGNC:43479) is a microRNA gene on chromosome 6p24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100846998 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43479
Approved symbol	MIR5689
Name	microRNA 5689
Location	6p24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5689
Ensembl gene	ENSG00000263705
Ensembl biotype	miRNA
Entrez	100846998
RNAcentral	URS000075B8DC — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581998

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581998 — 1 exons

Exon	Start	End
ENSE00002725807	10439717	10439794

Expression profiles

Bgee: expression breadth broad, 15 present calls, max score 78.40.

Top tissues by expression

15 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	78.40	gold quality
monocyte	CL:0000576	77.10	gold quality
skin of leg	UBERON:0001511	67.54	gold quality
transverse colon	UBERON:0001157	66.96	gold quality
blood	UBERON:0000178	66.40	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.39	gold quality
lower esophagus muscularis layer	UBERON:0035833	63.54	gold quality
right ovary	UBERON:0002118	62.16	gold quality
thoracic mammary gland	UBERON:0005200	61.25	gold quality
right hemisphere of cerebellum	UBERON:0014890	59.74	gold quality
tibial nerve	UBERON:0001323	58.98	gold quality
left lobe of thyroid gland	UBERON:0001120	57.36	gold quality
substantia nigra	UBERON:0002038	57.13	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	54.27	gold quality
left testis	UBERON:0004533	42.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.