MIR5689HG

Summary

MIR5689HG (MIR5689 host gene, HGNC:52007) is a long non-coding RNA gene on chromosome 6p24.3.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:52007
Approved symbol	MIR5689HG
Name	MIR5689 host gene
Location	6p24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229401
Entrez	106660610
RNAcentral	URS000059710D — lncRNA, 656 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 82.98.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.98	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	63.29	gold quality
monocyte	CL:0000576	54.10	gold quality
islet of Langerhans	UBERON:0000006	54.09	gold quality
gall bladder	UBERON:0002110	52.92	gold quality
placenta	UBERON:0001987	52.29	gold quality
ectocervix	UBERON:0012249	50.98	gold quality
blood	UBERON:0000178	49.36	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	49.10	gold quality
liver	UBERON:0002107	48.72	silver quality
vermiform appendix	UBERON:0001154	48.70	gold quality
muscle of leg	UBERON:0001383	48.19	gold quality
fundus of stomach	UBERON:0001160	47.77	gold quality
urinary bladder	UBERON:0001255	47.57	gold quality
cortex of kidney	UBERON:0001225	47.54	gold quality
lymph node	UBERON:0000029	46.97	silver quality
right lobe of liver	UBERON:0001114	46.82	silver quality
gastrocnemius	UBERON:0001388	46.34	gold quality
left coronary artery	UBERON:0001626	46.27	gold quality
left uterine tube	UBERON:0001303	46.18	gold quality
body of stomach	UBERON:0001161	46.06	gold quality
stomach	UBERON:0000945	45.86	gold quality
primary visual cortex	UBERON:0002436	45.33	silver quality
prefrontal cortex	UBERON:0000451	45.28	silver quality
esophagus mucosa	UBERON:0002469	45.16	gold quality
kidney	UBERON:0002113	44.69	gold quality
esophagus	UBERON:0001043	44.41	silver quality
heart	UBERON:0000948	44.10	gold quality
heart left ventricle	UBERON:0002084	44.02	gold quality
mucosa of transverse colon	UBERON:0004991	44.01	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.45

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000147955 (6:10440797 G>A), RS1000435129 (6:10453106 G>C), RS1000485803 (6:10445645 C>T), RS1000488115 (6:10456945 C>A), RS1000514628 (6:10446039 G>A), RS1000661215 (6:10445272 A>T), RS1000685682 (6:10432417 C>A), RS1000722691 (6:10452508 C>T), RS1000728830 (6:10446701 G>T), RS1000831584 (6:10433377 G>A), RS1000963764 (6:10433158 T>C), RS1001221908 (6:10451632 C>A,T), RS1001374136 (6:10445927 T>C), RS1001447318 (6:10439269 T>C), RS1001754795 (6:10451867 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

5 total (human), top 5 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
S-(1,2-dichlorovinyl)cysteine	increases expression	1
Smoke	decreases expression	1
Cadmium Chloride	increases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.