MIR569

Summary

MIR569 (microRNA 569, HGNC:32825) is a microRNA gene on chromosome 3q26.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693154 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32825
Approved symbol	MIR569
Name	microRNA 569
Location	3q26.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-569
Ensembl gene	ENSG00000207963
Ensembl biotype	miRNA
Entrez	693154
RNAcentral	URS0000685928 — miRNA, 96 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385228

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385228 — 1 exons

Exon	Start	End
ENSE00001500234	171106664	171106759

Expression profiles

Bgee: expression breadth broad, 83 present calls, max score 85.25.

Top tissues by expression

83 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
kidney	UBERON:0002113	85.25	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.38	gold quality
corpus callosum	UBERON:0002336	83.09	gold quality
adult mammalian kidney	UBERON:0000082	82.62	gold quality
blood	UBERON:0000178	77.63	gold quality
adrenal tissue	UBERON:0018303	76.83	gold quality
vermiform appendix	UBERON:0001154	76.01	gold quality
gastrocnemius	UBERON:0001388	74.92	gold quality
calcaneal tendon	UBERON:0003701	74.90	gold quality
heart	UBERON:0000948	73.98	gold quality
left coronary artery	UBERON:0001626	72.67	gold quality
right atrium auricular region	UBERON:0006631	72.51	gold quality
smooth muscle tissue	UBERON:0001135	72.30	gold quality
stomach	UBERON:0000945	72.00	gold quality
substantia nigra	UBERON:0002038	71.90	gold quality
right adrenal gland cortex	UBERON:0035827	71.74	gold quality
right ovary	UBERON:0002118	70.93	gold quality
heart left ventricle	UBERON:0002084	70.68	gold quality
liver	UBERON:0002107	70.53	gold quality
tibial artery	UBERON:0007610	70.47	gold quality
body of pancreas	UBERON:0001150	70.38	gold quality
ascending aorta	UBERON:0001496	69.98	gold quality
body of stomach	UBERON:0001161	69.03	gold quality
right adrenal gland	UBERON:0001233	68.67	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.33	gold quality
intestine	UBERON:0000160	68.11	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.01	gold quality
lower esophagus	UBERON:0013473	67.95	gold quality
left adrenal gland cortex	UBERON:0035825	67.65	gold quality
left adrenal gland	UBERON:0001234	67.62	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.44

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Results demonstrate that miR-569 is overexpressed in a subset of ovarian and breast cancers and alters cell survival and proliferation through downregulation of TP53INP1 expression. (PMID:25490449)
• microRNA-569 inhibits tumor metastasis in pancreatic cancer by directly targeting NUSAP1. (PMID:35483343)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.