MIR5690

Summary

MIR5690 (microRNA 5690, HGNC:43490) is a microRNA gene on chromosome 6p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847048 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43490
Approved symbol	MIR5690
Name	microRNA 5690
Location	6p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5690
Ensembl gene	ENSG00000265527
Ensembl biotype	miRNA
Entrez	100847048
RNAcentral	URS000075F055 — ncRNA, 73 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583739

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583739 — 1 exons

Exon	Start	End
ENSE00002688511	35664717	35664789

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 98.17.

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.17	gold quality
skeletal muscle tissue	UBERON:0001134	92.29	gold quality
calcaneal tendon	UBERON:0003701	90.73	gold quality
adrenal tissue	UBERON:0018303	82.19	gold quality
liver	UBERON:0002107	81.79	gold quality
blood	UBERON:0000178	80.54	gold quality
bone marrow	UBERON:0002371	80.48	gold quality
muscle of leg	UBERON:0001383	79.16	gold quality
monocyte	CL:0000576	77.27	gold quality
gastrocnemius	UBERON:0001388	76.60	gold quality
kidney	UBERON:0002113	75.91	gold quality
endometrium	UBERON:0001295	75.73	gold quality
adult mammalian kidney	UBERON:0000082	75.70	gold quality
tibial nerve	UBERON:0001323	74.67	gold quality
right ovary	UBERON:0002118	74.42	gold quality
lymph node	UBERON:0000029	73.56	gold quality
heart left ventricle	UBERON:0002084	73.44	gold quality
stomach	UBERON:0000945	73.36	gold quality
prefrontal cortex	UBERON:0000451	72.72	gold quality
skin of abdomen	UBERON:0001416	72.50	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.43	gold quality
heart	UBERON:0000948	72.41	gold quality
lung	UBERON:0002048	72.40	gold quality
zone of skin	UBERON:0000014	72.23	gold quality
ectocervix	UBERON:0012249	72.10	gold quality
skin of leg	UBERON:0001511	72.06	gold quality
ovary	UBERON:0000992	72.03	gold quality
left coronary artery	UBERON:0001626	72.00	gold quality
left ovary	UBERON:0002119	71.55	gold quality
popliteal artery	UBERON:0002250	71.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.94

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.