MIR5692A1

Summary

MIR5692A1 (microRNA 5692a-1, HGNC:43533) is a microRNA gene on chromosome 7q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847066 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43533
Approved symbol	MIR5692A1
Name	microRNA 5692a-1
Location	7q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5692a-1
Ensembl gene	ENSG00000266318
Ensembl biotype	miRNA
Entrez	100847066
RNAcentral	URS000075D061 — ncRNA, 69 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580523

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580523 — 1 exons

Exon	Start	End
ENSE00002699288	97963658	97963726

Expression profiles

Bgee: expression breadth broad, 38 present calls, max score 86.28.

Top tissues by expression

38 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	86.28	gold quality
blood	UBERON:0000178	81.67	gold quality
stomach	UBERON:0000945	80.76	gold quality
kidney	UBERON:0002113	71.72	gold quality
heart	UBERON:0000948	71.45	gold quality
subcutaneous adipose tissue	UBERON:0002190	70.21	gold quality
tibial artery	UBERON:0007610	70.15	gold quality
left coronary artery	UBERON:0001626	70.09	gold quality
skin of abdomen	UBERON:0001416	70.06	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.24	gold quality
adult mammalian kidney	UBERON:0000082	68.52	gold quality
body of uterus	UBERON:0009853	67.62	gold quality
body of pancreas	UBERON:0001150	67.44	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.31	gold quality
transverse colon	UBERON:0001157	65.71	gold quality
endometrium	UBERON:0001295	65.52	gold quality
ascending aorta	UBERON:0001496	65.45	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.41	gold quality
tibial nerve	UBERON:0001323	64.82	gold quality
esophagus mucosa	UBERON:0002469	64.46	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.37	gold quality
omental fat pad	UBERON:0010414	63.26	gold quality
left uterine tube	UBERON:0001303	62.88	gold quality
spleen	UBERON:0002106	62.17	gold quality
minor salivary gland	UBERON:0001830	61.89	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.33	gold quality
myometrium	UBERON:0001296	60.70	gold quality
vagina	UBERON:0000996	60.66	gold quality
liver	UBERON:0002107	60.50	gold quality
caudate nucleus	UBERON:0001873	59.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• showed that overexpressed miR-5692a accelerated cell cycle and inhibited cell apoptosis (PMID:30941968)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.