MIR5692A2

Summary

MIR5692A2 (microRNA 5692a-2, HGNC:43466) is a microRNA gene on chromosome 8p23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847038 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43466
Approved symbol	MIR5692A2
Name	microRNA 5692a-2
Location	8p23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5692a-2
Ensembl gene	ENSG00000264512
Ensembl biotype	miRNA
Entrez	100847038
RNAcentral	URS0000759C98 — miRNA, 59 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582551

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582551 — 1 exons

Exon	Start	End
ENSE00002706193	12719132	12719190

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 78.90.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	78.90	gold quality
blood	UBERON:0000178	71.21	gold quality
thoracic mammary gland	UBERON:0005200	70.37	gold quality
tibial artery	UBERON:0007610	69.27	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.94	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.81	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.73	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.65	gold quality
transverse colon	UBERON:0001157	67.25	gold quality
amygdala	UBERON:0001876	67.12	gold quality
thoracic aorta	UBERON:0001515	66.65	gold quality
Ammon’s horn	UBERON:0001954	65.67	gold quality
left ovary	UBERON:0002119	65.65	gold quality
skin of abdomen	UBERON:0001416	65.20	gold quality
cerebellar hemisphere	UBERON:0002245	65.10	gold quality
tibial nerve	UBERON:0001323	64.89	gold quality
zone of skin	UBERON:0000014	64.09	gold quality
vagina	UBERON:0000996	64.03	gold quality
substantia nigra	UBERON:0002038	63.81	gold quality
left lobe of thyroid gland	UBERON:0001120	63.60	gold quality
ascending aorta	UBERON:0001496	63.55	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.50	gold quality
thyroid gland	UBERON:0002046	63.18	gold quality
esophagus mucosa	UBERON:0002469	62.64	gold quality
body of uterus	UBERON:0009853	62.52	gold quality
skin of leg	UBERON:0001511	62.34	gold quality
pituitary gland	UBERON:0000007	58.94	gold quality
right testis	UBERON:0004534	49.96	gold quality
left testis	UBERON:0004533	48.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• showed that overexpressed miR-5692a accelerated cell cycle and inhibited cell apoptosis (PMID:30941968)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.