MIR5692C1

Summary

MIR5692C1 (microRNA 5692c-1, HGNC:43506) is a microRNA gene on chromosome 5q31.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847082 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43506
Approved symbol	MIR5692C1
Name	microRNA 5692c-1
Location	5q31.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5692c-1
Ensembl gene	ENSG00000265924
Ensembl biotype	miRNA
Entrez	100847082
RNAcentral	URS000075AD54 — ncRNA, 91 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585309

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585309 — 1 exons

Exon	Start	End
ENSE00002692939	135802985	135803075

Expression profiles

Bgee: expression breadth broad, 19 present calls, max score 88.99.

Top tissues by expression

19 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	88.99	gold quality
endometrium	UBERON:0001295	77.22	gold quality
stomach	UBERON:0000945	76.76	gold quality
colon	UBERON:0001155	73.55	gold quality
intestine	UBERON:0000160	70.04	gold quality
left coronary artery	UBERON:0001626	66.69	gold quality
esophagus mucosa	UBERON:0002469	66.07	gold quality
thoracic mammary gland	UBERON:0005200	65.34	gold quality
skin of leg	UBERON:0001511	64.97	gold quality
zone of skin	UBERON:0000014	64.84	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.41	gold quality
skin of abdomen	UBERON:0001416	64.37	gold quality
caudate nucleus	UBERON:0001873	64.34	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.01	gold quality
omental fat pad	UBERON:0010414	59.30	gold quality
tibial nerve	UBERON:0001323	58.57	gold quality
lung	UBERON:0002048	58.43	gold quality
spleen	UBERON:0002106	56.86	gold quality
corpus callosum	UBERON:0002336	52.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.