MIR5692C2

Summary

MIR5692C2 (microRNA 5692c-2, HGNC:43448) is a microRNA gene on chromosome 7q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847017 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43448
Approved symbol	MIR5692C2
Name	microRNA 5692c-2
Location	7q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5692c-2
Ensembl gene	ENSG00000266668
Ensembl biotype	miRNA
Entrez	100847017
RNAcentral	URS000075EC55 — ncRNA, 77 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577959

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577959 — 1 exons

Exon	Start	End
ENSE00002696761	97964405	97964481

Expression profiles

Bgee: expression breadth broad, 69 present calls, max score 79.67.

Top tissues by expression

69 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.67	gold quality
adrenal tissue	UBERON:0018303	75.78	gold quality
prefrontal cortex	UBERON:0000451	74.29	gold quality
gastrocnemius	UBERON:0001388	73.51	gold quality
lung	UBERON:0002048	72.18	gold quality
lymph node	UBERON:0000029	72.03	gold quality
endometrium	UBERON:0001295	72.03	gold quality
islet of Langerhans	UBERON:0000006	70.60	gold quality
hypothalamus	UBERON:0001898	70.23	gold quality
stomach	UBERON:0000945	70.16	gold quality
heart left ventricle	UBERON:0002084	69.55	gold quality
heart	UBERON:0000948	69.25	gold quality
liver	UBERON:0002107	68.92	gold quality
body of pancreas	UBERON:0001150	68.62	gold quality
body of stomach	UBERON:0001161	67.99	gold quality
rectum	UBERON:0001052	67.93	gold quality
tibial artery	UBERON:0007610	67.90	gold quality
right atrium auricular region	UBERON:0006631	67.53	gold quality
nucleus accumbens	UBERON:0001882	67.43	gold quality
thoracic aorta	UBERON:0001515	66.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.01	gold quality
ascending aorta	UBERON:0001496	65.86	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.83	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.54	gold quality
left adrenal gland	UBERON:0001234	65.49	gold quality
intestine	UBERON:0000160	65.26	gold quality
colon	UBERON:0001155	65.25	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.15	gold quality
lower esophagus mucosa	UBERON:0035834	65.05	gold quality
esophagus mucosa	UBERON:0002469	64.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.62

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.