MIR5693

Summary

MIR5693 (microRNA 5693, HGNC:43499) is a microRNA gene on chromosome 13q14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847003 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43499
Approved symbol	MIR5693
Name	microRNA 5693
Location	13q14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5693
Ensembl gene	ENSG00000266072
Ensembl biotype	miRNA
Entrez	100847003
RNAcentral	URS0000759B7D — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577722

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577722 — 1 exons

Exon	Start	End
ENSE00002711200	51348567	51348639

Expression profiles

Bgee: expression breadth broad, 81 present calls, max score 81.88.

Top tissues by expression

81 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	81.88	gold quality
kidney	UBERON:0002113	77.31	gold quality
blood	UBERON:0000178	75.86	gold quality
monocyte	CL:0000576	75.58	gold quality
muscle of leg	UBERON:0001383	72.89	gold quality
calcaneal tendon	UBERON:0003701	72.59	gold quality
liver	UBERON:0002107	72.15	gold quality
gastrocnemius	UBERON:0001388	71.94	gold quality
tonsil	UBERON:0002372	71.91	gold quality
heart left ventricle	UBERON:0002084	71.82	gold quality
prefrontal cortex	UBERON:0000451	70.57	gold quality
adult mammalian kidney	UBERON:0000082	70.08	gold quality
ovary	UBERON:0000992	69.41	gold quality
left ovary	UBERON:0002119	69.24	gold quality
heart	UBERON:0000948	69.22	gold quality
stomach	UBERON:0000945	69.15	gold quality
right atrium auricular region	UBERON:0006631	69.13	gold quality
body of pancreas	UBERON:0001150	69.09	gold quality
substantia nigra	UBERON:0002038	68.92	gold quality
body of stomach	UBERON:0001161	68.35	gold quality
myometrium	UBERON:0001296	68.21	gold quality
lung	UBERON:0002048	68.21	gold quality
endometrium	UBERON:0001295	67.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.62	gold quality
caudate nucleus	UBERON:0001873	67.58	gold quality
right coronary artery	UBERON:0001625	67.47	gold quality
tibial artery	UBERON:0007610	67.38	gold quality
Ammon’s horn	UBERON:0001954	67.15	gold quality
putamen	UBERON:0001874	66.82	gold quality
transverse colon	UBERON:0001157	66.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.