MIR5694

Summary

MIR5694 (microRNA 5694, HGNC:43530) is a microRNA gene on chromosome 14q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847064 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43530
Approved symbol	MIR5694
Name	microRNA 5694
Location	14q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5694
Ensembl gene	ENSG00000265993
Ensembl biotype	miRNA
Entrez	100847064
RNAcentral	URS000075DF7F — ncRNA, 76 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581190

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581190 — 1 exons

Exon	Start	End
ENSE00002729841	67441855	67441930

Expression profiles

Bgee: expression breadth broad, 17 present calls, max score 74.58.

Top tissues by expression

17 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	74.58	gold quality
blood	UBERON:0000178	74.28	gold quality
skin of leg	UBERON:0001511	67.92	gold quality
transverse colon	UBERON:0001157	67.87	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.17	gold quality
right frontal lobe	UBERON:0002810	66.01	gold quality
left lobe of thyroid gland	UBERON:0001120	62.05	gold quality
cerebellar hemisphere	UBERON:0002245	61.90	gold quality
right adrenal gland cortex	UBERON:0035827	61.88	gold quality
right lobe of thyroid gland	UBERON:0001119	61.84	gold quality
thyroid gland	UBERON:0002046	61.60	gold quality
prostate gland	UBERON:0002367	61.49	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.46	gold quality
small intestine Peyer’s patch	UBERON:0003454	61.17	gold quality
spleen	UBERON:0002106	60.64	gold quality
pituitary gland	UBERON:0000007	57.95	gold quality
left testis	UBERON:0004533	45.57	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The miR-5694/AF9/Snail Axis Provides Metastatic Advantages and a Therapeutic Target in Basal-like Breast Cancer. (PMID:33221433)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.