MIR5695

Summary

MIR5695 (microRNA 5695, HGNC:43548) is a microRNA gene on chromosome 19p13.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847016 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43548
Approved symbol	MIR5695
Name	microRNA 5695
Location	19p13.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5695
Ensembl gene	ENSG00000266721
Ensembl biotype	miRNA
Entrez	100847016
RNAcentral	URS000075BDA7 — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579717

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579717 — 1 exons

Exon	Start	End
ENSE00002720708	12920320	12920404

Expression profiles

Bgee: expression breadth broad, 86 present calls, max score 91.93.

Top tissues by expression

86 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	91.93	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.52	gold quality
placenta	UBERON:0001987	81.61	gold quality
adrenal tissue	UBERON:0018303	79.07	gold quality
calcaneal tendon	UBERON:0003701	79.02	gold quality
blood	UBERON:0000178	76.01	gold quality
endometrium	UBERON:0001295	74.83	gold quality
monocyte	CL:0000576	74.10	gold quality
muscle of leg	UBERON:0001383	74.02	gold quality
islet of Langerhans	UBERON:0000006	72.65	gold quality
gastrocnemius	UBERON:0001388	72.24	gold quality
fundus of stomach	UBERON:0001160	71.42	gold quality
adult mammalian kidney	UBERON:0000082	70.78	gold quality
adrenal gland	UBERON:0002369	70.28	gold quality
heart	UBERON:0000948	69.57	gold quality
body of pancreas	UBERON:0001150	69.56	gold quality
stomach	UBERON:0000945	69.43	gold quality
granulocyte	CL:0000094	68.61	gold quality
heart left ventricle	UBERON:0002084	68.51	gold quality
myometrium	UBERON:0001296	68.39	gold quality
tibial artery	UBERON:0007610	68.19	gold quality
right atrium auricular region	UBERON:0006631	68.18	gold quality
lung	UBERON:0002048	68.08	gold quality
left adrenal gland cortex	UBERON:0035825	67.89	gold quality
left adrenal gland	UBERON:0001234	67.04	gold quality
amygdala	UBERON:0001876	66.87	gold quality
substantia nigra	UBERON:0002038	66.87	gold quality
apex of heart	UBERON:0002098	66.59	gold quality
body of stomach	UBERON:0001161	66.52	gold quality
anterior cingulate cortex	UBERON:0009835	66.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.59

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.