MIR5696

Summary

MIR5696 (microRNA 5696, HGNC:43516) is a microRNA gene on chromosome 2q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847007 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43516
Approved symbol	MIR5696
Name	microRNA 5696
Location	2q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5696
Ensembl gene	ENSG00000264857
Ensembl biotype	miRNA
Entrez	100847007
RNAcentral	URS000075E5F5 — miRNA, 85 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578474

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578474 — 1 exons

Exon	Start	End
ENSE00002727615	101309450	101309534

Expression profiles

Bgee: expression breadth broad, 43 present calls, max score 76.61.

Top tissues by expression

43 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left adrenal gland	UBERON:0001234	76.61	gold quality
muscle of leg	UBERON:0001383	76.30	gold quality
islet of Langerhans	UBERON:0000006	75.96	gold quality
heart	UBERON:0000948	75.84	gold quality
gastrocnemius	UBERON:0001388	74.91	gold quality
monocyte	CL:0000576	74.33	gold quality
heart left ventricle	UBERON:0002084	73.33	gold quality
blood	UBERON:0000178	73.14	gold quality
right lobe of liver	UBERON:0001114	71.54	gold quality
prefrontal cortex	UBERON:0000451	70.40	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	70.16	gold quality
body of stomach	UBERON:0001161	69.79	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.33	gold quality
smooth muscle tissue	UBERON:0001135	68.85	gold quality
tonsil	UBERON:0002372	68.69	gold quality
granulocyte	CL:0000094	68.61	gold quality
ascending aorta	UBERON:0001496	68.40	gold quality
small intestine	UBERON:0002108	68.29	gold quality
skin of abdomen	UBERON:0001416	68.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.45	gold quality
caudate nucleus	UBERON:0001873	67.13	gold quality
adipose tissue	UBERON:0001013	67.02	gold quality
endometrium	UBERON:0001295	66.76	gold quality
omental fat pad	UBERON:0010414	66.62	gold quality
tibial artery	UBERON:0007610	66.22	gold quality
descending thoracic aorta	UBERON:0002345	66.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.98	gold quality
right frontal lobe	UBERON:0002810	65.92	gold quality
nucleus accumbens	UBERON:0001882	65.88	gold quality
esophagus mucosa	UBERON:0002469	65.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.51

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.