MIR5697

Summary

MIR5697 (microRNA 5697, HGNC:43509) is a microRNA gene on chromosome 1p36.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847055 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43509
Approved symbol	MIR5697
Name	microRNA 5697
Location	1p36.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5697
Ensembl gene	ENSG00000265521
Ensembl biotype	miRNA
Entrez	100847055
RNAcentral	URS000075DD5F — miRNA, 78 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578045

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578045 — 1 exons

Exon	Start	End
ENSE00002688669	9967381	9967458

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 93.59.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.59	gold quality
skeletal muscle tissue	UBERON:0001134	83.80	gold quality
vermiform appendix	UBERON:0001154	83.16	gold quality
adrenal tissue	UBERON:0018303	80.19	gold quality
calcaneal tendon	UBERON:0003701	78.68	gold quality
placenta	UBERON:0001987	78.44	gold quality
blood	UBERON:0000178	77.50	gold quality
muscle of leg	UBERON:0001383	76.92	gold quality
tibial artery	UBERON:0007610	75.43	gold quality
gastrocnemius	UBERON:0001388	73.77	gold quality
endometrium	UBERON:0001295	73.44	gold quality
heart left ventricle	UBERON:0002084	72.07	gold quality
leukocyte	CL:0000738	71.69	gold quality
monocyte	CL:0000576	71.59	gold quality
kidney	UBERON:0002113	71.32	gold quality
stomach	UBERON:0000945	71.13	gold quality
liver	UBERON:0002107	71.11	gold quality
gall bladder	UBERON:0002110	70.77	gold quality
heart	UBERON:0000948	70.60	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.49	gold quality
lung	UBERON:0002048	69.61	gold quality
body of pancreas	UBERON:0001150	68.62	gold quality
body of stomach	UBERON:0001161	68.38	gold quality
rectum	UBERON:0001052	67.72	gold quality
left adrenal gland	UBERON:0001234	67.12	gold quality
intestine	UBERON:0000160	66.93	gold quality
left adrenal gland cortex	UBERON:0035825	66.88	gold quality
urinary bladder	UBERON:0001255	66.78	gold quality
colon	UBERON:0001155	66.63	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.