MIR5698

Summary

MIR5698 (microRNA 5698, HGNC:43487) is a microRNA gene on chromosome 1q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847024 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43487
Approved symbol	MIR5698
Name	microRNA 5698
Location	1q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5698
Ensembl gene	ENSG00000263987
Ensembl biotype	miRNA
Entrez	100847024
RNAcentral	URS000075BD15 — miRNA, 72 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577643

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577643 — 1 exons

Exon	Start	End
ENSE00002695008	154104521	154104592

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 79.75.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Brodmann (1909) area 9	UBERON:0013540	79.75	gold quality
blood	UBERON:0000178	73.27	gold quality
monocyte	CL:0000576	72.41	gold quality
Ammon’s horn	UBERON:0001954	71.71	gold quality
islet of Langerhans	UBERON:0000006	71.09	gold quality
amygdala	UBERON:0001876	68.93	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.87	gold quality
transverse colon	UBERON:0001157	68.42	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.46	gold quality
tibial artery	UBERON:0007610	67.37	gold quality
putamen	UBERON:0001874	67.20	gold quality
body of pancreas	UBERON:0001150	67.16	gold quality
corpus callosum	UBERON:0002336	66.78	gold quality
ascending aorta	UBERON:0001496	66.75	gold quality
fundus of stomach	UBERON:0001160	66.58	gold quality
skin of abdomen	UBERON:0001416	66.54	gold quality
substantia nigra	UBERON:0002038	66.45	gold quality
right atrium auricular region	UBERON:0006631	66.33	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.78	gold quality
upper lobe of left lung	UBERON:0008952	65.47	gold quality
left lobe of thyroid gland	UBERON:0001120	65.16	gold quality
omental fat pad	UBERON:0010414	64.67	gold quality
nucleus accumbens	UBERON:0001882	64.58	gold quality
body of uterus	UBERON:0009853	64.25	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.85	gold quality
anterior cingulate cortex	UBERON:0009835	63.77	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.49	gold quality
endocervix	UBERON:0000458	63.45	gold quality
tibial nerve	UBERON:0001323	63.19	gold quality
thyroid gland	UBERON:0002046	63.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.22

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.