MIR5699

Summary

MIR5699 (microRNA 5699, HGNC:43456) is a microRNA gene on chromosome 10p15.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847086 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43456
Approved symbol	MIR5699
Name	microRNA 5699
Location	10p15.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5699
Ensembl gene	ENSG00000263511
Ensembl biotype	miRNA
Entrez	100847086
RNAcentral	URS000075E251 — miRNA, 90 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578903

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578903 — 1 exons

Exon	Start	End
ENSE00002713311	641689	641778

Expression profiles

Bgee: expression breadth broad, 78 present calls, max score 93.77.

Top tissues by expression

78 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.77	gold quality
blood	UBERON:0000178	84.14	gold quality
kidney	UBERON:0002113	83.99	gold quality
corpus callosum	UBERON:0002336	80.19	gold quality
stomach	UBERON:0000945	79.18	gold quality
liver	UBERON:0002107	78.88	gold quality
prefrontal cortex	UBERON:0000451	78.11	gold quality
lung	UBERON:0002048	76.70	gold quality
adult mammalian kidney	UBERON:0000082	76.46	gold quality
gastrocnemius	UBERON:0001388	72.76	gold quality
body of pancreas	UBERON:0001150	72.46	gold quality
adrenal tissue	UBERON:0018303	71.93	gold quality
calcaneal tendon	UBERON:0003701	71.73	gold quality
heart	UBERON:0000948	71.41	gold quality
endometrium	UBERON:0001295	69.70	gold quality
right atrium auricular region	UBERON:0006631	69.49	gold quality
popliteal artery	UBERON:0002250	68.94	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.93	gold quality
tibial artery	UBERON:0007610	68.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.45	gold quality
heart left ventricle	UBERON:0002084	68.13	gold quality
amygdala	UBERON:0001876	67.98	gold quality
colon	UBERON:0001155	67.91	gold quality
ascending aorta	UBERON:0001496	67.89	gold quality
intestine	UBERON:0000160	67.77	gold quality
right lobe of liver	UBERON:0001114	67.73	gold quality
esophagus	UBERON:0001043	67.48	gold quality
transverse colon	UBERON:0001157	67.46	gold quality
frontal cortex	UBERON:0001870	67.44	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.