MIR570

Summary

MIR570 (microRNA 570, HGNC:32826) is a microRNA gene on chromosome 3q29.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693155 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32826
Approved symbol	MIR570
Name	microRNA 570
Location	3q29
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-570
Ensembl gene	ENSG00000207650
Ensembl biotype	miRNA
OMIM	614538
Entrez	693155
RNAcentral	URS0000759B29 — miRNA, 97 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384917

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384917 — 1 exons

Exon	Start	End
ENSE00001499924	195699401	195699497

Expression profiles

Bgee: expression breadth ubiquitous, 118 present calls, max score 98.30.

Top tissues by expression

118 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	98.30	gold quality
right uterine tube	UBERON:0001302	97.46	gold quality
metanephros cortex	UBERON:0010533	96.75	gold quality
endometrium	UBERON:0001295	96.50	gold quality
fundus of stomach	UBERON:0001160	96.32	gold quality
small intestine Peyer’s patch	UBERON:0003454	96.30	gold quality
transverse colon	UBERON:0001157	96.21	gold quality
left ovary	UBERON:0002119	96.18	gold quality
minor salivary gland	UBERON:0001830	96.13	gold quality
sural nerve	UBERON:0015488	96.08	gold quality
small intestine	UBERON:0002108	95.94	gold quality
saliva-secreting gland	UBERON:0001044	95.85	gold quality
left uterine tube	UBERON:0001303	95.83	gold quality
ectocervix	UBERON:0012249	95.70	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.66	gold quality
endocervix	UBERON:0000458	95.61	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.61	gold quality
ovary	UBERON:0000992	95.56	gold quality
vagina	UBERON:0000996	95.37	gold quality
stomach	UBERON:0000945	95.29	gold quality
body of stomach	UBERON:0001161	95.27	gold quality
intestine	UBERON:0000160	95.20	gold quality
right ovary	UBERON:0002118	95.19	gold quality
cerebellar hemisphere	UBERON:0002245	95.16	gold quality
right coronary artery	UBERON:0001625	94.98	gold quality
body of uterus	UBERON:0009853	94.95	gold quality
colon	UBERON:0001155	94.89	gold quality
body of pancreas	UBERON:0001150	94.76	gold quality
esophagus mucosa	UBERON:0002469	94.50	gold quality
right lung	UBERON:0002167	94.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.29

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• genetic polymorphisms influencing B7-H1 expression modify cancer susceptibility. (PMID:23430453)
• Suggest role for miR-570/KLF9 molecular network in controlling lung carcinoma progression. (PMID:26045791)
• our observation confirmed that miR-570 works as proliferation and metastatic suppressor in hepatocellular carcinoma cells through directly targeting B7-H1 in hepatocellular carcinoma cell (PMID:26084609)
• Overexpression of miR-570 significantly decreased CYP2E1 protein levels in HEK cells. (PMID:26199425)
• Genetic variants of miR-570 (rs4143815), miR-27a and miR-181a polymorphisms did not individually associate with overall risk of gallbladder carcinoma. However, all three genetic variants may interact to confer a higher risk of gallbladder carcinoma. (PMID:26288960)
• Overexpression of miR-570-3p in platelets resulted in reduced levels of ATP5L mRNA and concomitant ATP loss. (PMID:27561077)
• miR-570 plays an important role in the proliferation, angiogenesis, and immune escape of hepatocellular carcinoma. (PMID:29874097)
• data suggest that inhibiting miR-570-3p rejuvenates cells via restoration of sirtuin-1, reducing many of the abnormalities associated with cellular senescence (PMID:30156909)
• Positive correlation between miR-570 and prognosis of colon cancer: inhibition of cell proliferation and invasion. (PMID:34471998)
• Construction and Analysis of lncRNA-Associated ceRNA Network in Atherosclerotic Plaque Formation. (PMID:35463977)
• MicroRNA-570 targets the HSP chaperone network, increases proteotoxic stress and inhibits mammary tumor cell migration. (PMID:36114410)
• Circ_ATAD3B inhibits cell proliferation of breast cancer via mediating the miR-570-3p/MX2 axis. (PMID:37286092)
• Mechanism of circRNA_SMG6 mediating lung macrophage ECM degradation via miR-570-3p in microplastics-induced emphysema. (PMID:38685156)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.