MIR5700

Summary

MIR5700 (microRNA 5700, HGNC:43521) is a microRNA gene on chromosome 12q22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847031 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43521
Approved symbol	MIR5700
Name	microRNA 5700
Location	12q22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5700
Ensembl gene	ENSG00000266099
Ensembl biotype	miRNA
Entrez	100847031
RNAcentral	URS000075C3BB — ncRNA, 71 nt, 10 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582250

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582250 — 1 exons

Exon	Start	End
ENSE00002718789	94561789	94561859

Expression profiles

Bgee: expression breadth broad, 51 present calls, max score 77.18.

Top tissues by expression

51 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	77.18	gold quality
blood	UBERON:0000178	73.90	gold quality
islet of Langerhans	UBERON:0000006	72.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.16	gold quality
gastrocnemius	UBERON:0001388	71.90	gold quality
endometrium	UBERON:0001295	71.14	gold quality
body of pancreas	UBERON:0001150	70.35	gold quality
myometrium	UBERON:0001296	70.24	gold quality
monocyte	CL:0000576	69.41	gold quality
apex of heart	UBERON:0002098	69.18	gold quality
tibial artery	UBERON:0007610	69.10	gold quality
ascending aorta	UBERON:0001496	68.68	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.10	gold quality
body of stomach	UBERON:0001161	67.77	gold quality
rectum	UBERON:0001052	67.59	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.77	gold quality
anterior cingulate cortex	UBERON:0009835	66.65	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.32	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.62	gold quality
amygdala	UBERON:0001876	65.35	gold quality
caudate nucleus	UBERON:0001873	65.33	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.13	gold quality
frontal cortex	UBERON:0001870	65.07	gold quality
skin of leg	UBERON:0001511	64.94	gold quality
skin of abdomen	UBERON:0001416	64.89	gold quality
omental fat pad	UBERON:0010414	64.88	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.23	gold quality
thoracic mammary gland	UBERON:0005200	64.18	gold quality
right ovary	UBERON:0002118	64.17	gold quality
esophagus mucosa	UBERON:0002469	63.72	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.