MIR5701-1

Summary

MIR5701-1 (microRNA 5701-1, HGNC:43522) is a microRNA gene on chromosome 15q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847060 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43522
Approved symbol	MIR5701-1
Name	microRNA 5701-1
Location	15q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5701-1
Ensembl gene	ENSG00000266545
Ensembl biotype	miRNA
Entrez	100847060
RNAcentral	URS000075E169 — miRNA, 82 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000585138

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000585138 — 1 exons

Exon	Start	End
ENSE00002722453	20940252	20940333

Expression profiles

Bgee: expression breadth tissue_specific, 7 present calls, max score 67.46.

Top tissues by expression

7 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	67.46	gold quality
gastrocnemius	UBERON:0001388	65.86	gold quality
small intestine Peyer’s patch	UBERON:0003454	54.09	gold quality
tibial nerve	UBERON:0001323	51.73	gold quality
left lobe of thyroid gland	UBERON:0001120	50.13	gold quality
skin of abdomen	UBERON:0001416	48.70	gold quality
left testis	UBERON:0004533	26.61	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• the role of miR-5701, a novel miRNA, as a potential regulator of the mitochondrial and lysosomal function determining the fate of neurons which has important implication in the pathogenesis of Parkinson’s disease, is reported. (PMID:28710704)

Cross-species orthologs

0 orthologs

Paralogs (2): MIR5701-3 (ENSG00000264902), MIR5701-2 (ENSG00000277841)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.