MIR5702

Summary

MIR5702 (microRNA 5702, HGNC:43503) is a microRNA gene on chromosome 2q36.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847053 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43503
Approved symbol	MIR5702
Name	microRNA 5702
Location	2q36.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5702
Ensembl gene	ENSG00000263363
Ensembl biotype	miRNA
Entrez	100847053
RNAcentral	URS000075E543 — ncRNA, 84 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582265

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582265 — 1 exons

Exon	Start	End
ENSE00002734646	226658710	226658793

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 83.06.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	83.06	gold quality
lung	UBERON:0002048	82.01	gold quality
endometrium	UBERON:0001295	74.42	gold quality
right atrium auricular region	UBERON:0006631	73.88	gold quality
gastrocnemius	UBERON:0001388	73.84	gold quality
heart	UBERON:0000948	72.90	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	72.18	gold quality
heart left ventricle	UBERON:0002084	71.96	gold quality
tibial artery	UBERON:0007610	70.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.59	gold quality
popliteal artery	UBERON:0002250	69.12	gold quality
stomach	UBERON:0000945	68.70	gold quality
myometrium	UBERON:0001296	68.70	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.49	gold quality
body of pancreas	UBERON:0001150	68.35	gold quality
ascending aorta	UBERON:0001496	66.56	gold quality
zone of skin	UBERON:0000014	66.44	gold quality
body of stomach	UBERON:0001161	65.71	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.63	gold quality
intestine	UBERON:0000160	65.40	gold quality
thoracic mammary gland	UBERON:0005200	65.05	gold quality
cerebellar hemisphere	UBERON:0002245	64.56	gold quality
liver	UBERON:0002107	62.74	gold quality
body of uterus	UBERON:0009853	62.35	gold quality
skin of leg	UBERON:0001511	62.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	61.44	gold quality
omental fat pad	UBERON:0010414	61.38	gold quality
left lobe of thyroid gland	UBERON:0001120	59.52	gold quality
esophagus mucosa	UBERON:0002469	56.88	gold quality
tibial nerve	UBERON:0001323	49.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Down-regulation of miR-5702 is associated with clinical progression and poor prognosis in patients with non-small-cell lung cancer. (PMID:30915748)
• LncRNA LUCAT1 facilitates tumorigenesis and metastasis of triple-negative breast cancer through modulating miR-5702. (PMID:31399501)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.