MIR5703

Summary

MIR5703 (microRNA 5703, HGNC:43475) is a microRNA gene on chromosome 2q36.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847081 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43475
Approved symbol	MIR5703
Name	microRNA 5703
Location	2q36.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5703
Ensembl gene	ENSG00000284092
Ensembl biotype	miRNA
Entrez	100847081
RNAcentral	URS000075BAA3 — ncRNA, 56 nt, 10 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000640052

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000640052 — 1 exons

Exon	Start	End
ENSE00003809623	227472132	227472187

Expression profiles

Bgee: expression breadth broad, 30 present calls, max score 73.45.

FANTOM5 (CAGE): breadth broad, TPM avg 0.4481 / max 30.4939, expressed in 197 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
25742	0.4481	197

Top tissues by expression

30 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	73.45	gold quality
gastrocnemius	UBERON:0001388	71.78	gold quality
tibial artery	UBERON:0007610	71.12	gold quality
popliteal artery	UBERON:0002250	70.92	gold quality
vagina	UBERON:0000996	69.42	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.92	gold quality
esophagus mucosa	UBERON:0002469	68.27	gold quality
body of stomach	UBERON:0001161	68.24	gold quality
ascending aorta	UBERON:0001496	68.22	gold quality
thoracic aorta	UBERON:0001515	67.69	gold quality
thoracic mammary gland	UBERON:0005200	67.69	gold quality
omental fat pad	UBERON:0010414	66.95	gold quality
putamen	UBERON:0001874	66.71	gold quality
right ovary	UBERON:0002118	66.12	gold quality
transverse colon	UBERON:0001157	66.07	gold quality
tibial nerve	UBERON:0001323	66.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.84	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.46	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.37	gold quality
upper lobe of left lung	UBERON:0008952	64.13	gold quality
pituitary gland	UBERON:0000007	64.02	gold quality
spleen	UBERON:0002106	63.48	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.43	gold quality
prostate gland	UBERON:0002367	62.63	gold quality
hypothalamus	UBERON:0001898	62.30	gold quality
left testis	UBERON:0004533	54.46	gold quality
testis	UBERON:0000473	54.37	gold quality
left lobe of thyroid gland	UBERON:0001120	54.36	gold quality
right testis	UBERON:0004534	51.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway. (PMID:32585413)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.