MIR5704

Summary

MIR5704 (microRNA 5704, HGNC:43469) is a microRNA gene on chromosome 3q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847040 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43469
Approved symbol	MIR5704
Name	microRNA 5704
Location	3q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5704
Ensembl gene	ENSG00000265859
Ensembl biotype	miRNA
Entrez	100847040
RNAcentral	URS000075D26D — ncRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584029

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584029 — 1 exons

Exon	Start	End
ENSE00002703136	131985855	131985931

Expression profiles

Bgee: expression breadth broad, 24 present calls, max score 81.66.

Top tissues by expression

24 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	81.66	gold quality
monocyte	CL:0000576	73.46	gold quality
esophagus mucosa	UBERON:0002469	69.84	gold quality
body of stomach	UBERON:0001161	69.77	gold quality
stomach	UBERON:0000945	69.70	gold quality
right lobe of liver	UBERON:0001114	66.86	gold quality
transverse colon	UBERON:0001157	66.28	gold quality
body of pancreas	UBERON:0001150	66.22	gold quality
prostate gland	UBERON:0002367	65.78	gold quality
ascending aorta	UBERON:0001496	64.47	gold quality
skin of leg	UBERON:0001511	64.41	gold quality
left ovary	UBERON:0002119	64.38	gold quality
amygdala	UBERON:0001876	64.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	63.68	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	63.23	gold quality
thoracic mammary gland	UBERON:0005200	62.18	gold quality
caudate nucleus	UBERON:0001873	62.11	gold quality
right atrium auricular region	UBERON:0006631	61.78	gold quality
brain	UBERON:0000955	59.96	gold quality
upper lobe of left lung	UBERON:0008952	56.64	gold quality
pituitary gland	UBERON:0000007	53.95	gold quality
right testis	UBERON:0004534	46.88	gold quality
testis	UBERON:0000473	44.57	gold quality
left testis	UBERON:0004533	44.15	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.