MIR5706

Summary

MIR5706 (microRNA 5706, HGNC:43500) is a microRNA gene on chromosome 5q23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847085 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43500
Approved symbol	MIR5706
Name	microRNA 5706
Location	5q23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5706
Ensembl gene	ENSG00000264536
Ensembl biotype	miRNA
Entrez	100847085
RNAcentral	URS000075E25C — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579841

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579841 — 1 exons

Exon	Start	End
ENSE00002697622	119154637	119154716

Expression profiles

Bgee: expression breadth broad, 64 present calls, max score 95.97.

Top tissues by expression

64 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.97	gold quality
sural nerve	UBERON:0015488	93.99	gold quality
corpus callosum	UBERON:0002336	83.86	gold quality
kidney	UBERON:0002113	82.20	gold quality
calcaneal tendon	UBERON:0003701	81.34	gold quality
adult mammalian kidney	UBERON:0000082	80.97	gold quality
blood	UBERON:0000178	80.63	gold quality
adrenal tissue	UBERON:0018303	80.55	gold quality
liver	UBERON:0002107	78.88	gold quality
stomach	UBERON:0000945	76.64	gold quality
monocyte	CL:0000576	75.23	gold quality
gastrocnemius	UBERON:0001388	74.98	gold quality
heart	UBERON:0000948	74.16	gold quality
intestine	UBERON:0000160	71.88	gold quality
lung	UBERON:0002048	70.17	gold quality
amygdala	UBERON:0001876	70.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.93	gold quality
right frontal lobe	UBERON:0002810	69.28	gold quality
colon	UBERON:0001155	68.38	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.65	gold quality
body of stomach	UBERON:0001161	67.55	gold quality
heart left ventricle	UBERON:0002084	67.04	gold quality
body of pancreas	UBERON:0001150	66.92	gold quality
tibial artery	UBERON:0007610	66.05	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.75	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.17	gold quality
prostate gland	UBERON:0002367	65.09	gold quality
skin of leg	UBERON:0001511	65.08	gold quality
ascending aorta	UBERON:0001496	64.86	gold quality
thoracic mammary gland	UBERON:0005200	64.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.