MIR5707

Summary

MIR5707 (microRNA 5707, HGNC:43449) is a microRNA gene on chromosome 7q36.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847032 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43449
Approved symbol	MIR5707
Name	microRNA 5707
Location	7q36.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5707
Ensembl gene	ENSG00000265598
Ensembl biotype	miRNA
Entrez	100847032
RNAcentral	URS000075B4BF — ncRNA, 81 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582433

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582433 — 1 exons

Exon	Start	End
ENSE00002711451	158591616	158591696

Expression profiles

Bgee: expression breadth broad, 44 present calls, max score 81.47.

Top tissues by expression

44 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	81.47	gold quality
monocyte	CL:0000576	78.56	gold quality
left testis	UBERON:0004533	78.45	gold quality
testis	UBERON:0000473	78.23	gold quality
right testis	UBERON:0004534	77.74	gold quality
amygdala	UBERON:0001876	76.96	gold quality
islet of Langerhans	UBERON:0000006	75.07	gold quality
right atrium auricular region	UBERON:0006631	74.49	gold quality
gastrocnemius	UBERON:0001388	72.65	gold quality
stomach	UBERON:0000945	70.27	gold quality
body of stomach	UBERON:0001161	69.94	gold quality
body of pancreas	UBERON:0001150	69.64	gold quality
minor salivary gland	UBERON:0001830	68.28	gold quality
transverse colon	UBERON:0001157	68.03	gold quality
blood	UBERON:0000178	67.46	gold quality
colon	UBERON:0001155	67.36	gold quality
intestine	UBERON:0000160	67.32	gold quality
tibial artery	UBERON:0007610	66.97	gold quality
thoracic mammary gland	UBERON:0005200	66.63	gold quality
esophagus mucosa	UBERON:0002469	66.43	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.88	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.87	gold quality
putamen	UBERON:0001874	65.52	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.85	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.75	gold quality
muscle layer of sigmoid colon	UBERON:0035805	64.54	gold quality
substantia nigra	UBERON:0002038	64.53	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.43	gold quality
caudate nucleus	UBERON:0001873	64.03	gold quality
anterior cingulate cortex	UBERON:0009835	63.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.