MIR5708

Summary

MIR5708 (microRNA 5708, HGNC:43511) is a microRNA gene on chromosome 8q21.13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100847056 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43511
Approved symbol	MIR5708
Name	microRNA 5708
Location	8q21.13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5708
Ensembl gene	ENSG00000265588
Ensembl biotype	miRNA
Entrez	100847056
RNAcentral	URS000075D3EA — miRNA, 85 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579723

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579723 — 1 exons

Exon	Start	End
ENSE00002694919	80241389	80241473

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 79.48.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	79.48	gold quality
muscle of leg	UBERON:0001383	75.47	gold quality
islet of Langerhans	UBERON:0000006	74.66	gold quality
putamen	UBERON:0001874	73.20	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	73.03	gold quality
gastrocnemius	UBERON:0001388	72.84	gold quality
heart left ventricle	UBERON:0002084	71.34	gold quality
corpus callosum	UBERON:0002336	71.25	gold quality
stomach	UBERON:0000945	70.02	gold quality
urinary bladder	UBERON:0001255	69.55	gold quality
body of stomach	UBERON:0001161	68.68	gold quality
ascending aorta	UBERON:0001496	68.08	gold quality
right atrium auricular region	UBERON:0006631	68.08	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.86	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.81	gold quality
tibial artery	UBERON:0007610	67.43	gold quality
Ammon’s horn	UBERON:0001954	67.35	gold quality
heart	UBERON:0000948	67.30	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.49	gold quality
right coronary artery	UBERON:0001625	66.22	gold quality
descending thoracic aorta	UBERON:0002345	65.91	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.44	gold quality
minor salivary gland	UBERON:0001830	65.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.35	gold quality
omental fat pad	UBERON:0010414	65.17	gold quality
nucleus accumbens	UBERON:0001882	65.14	gold quality
transverse colon	UBERON:0001157	64.97	gold quality
intestine	UBERON:0000160	64.86	gold quality
anterior cingulate cortex	UBERON:0009835	64.85	gold quality
esophagus mucosa	UBERON:0002469	64.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.80

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Genetic polymorphisms in MIR1208 and MIR5708 are associated with susceptibility to COPD in the Chinese population. (PMID:36115827)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.