MIR571

Summary

MIR571 (microRNA 571, HGNC:32827) is a microRNA gene on chromosome 4p16.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693156 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32827
Approved symbol	MIR571
Name	microRNA 571
Location	4p16.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-571
Ensembl gene	ENSG00000207642
Ensembl biotype	miRNA
Entrez	693156
RNAcentral	URS000075E6ED — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384910

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384910 — 1 exons

Exon	Start	End
ENSE00001499917	350157	350252

Expression profiles

Bgee: expression breadth broad, 97 present calls, max score 93.41.

Top tissues by expression

97 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.41	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	88.49	gold quality
adrenal tissue	UBERON:0018303	87.99	gold quality
monocyte	CL:0000576	79.27	gold quality
bone marrow	UBERON:0002371	79.18	gold quality
blood	UBERON:0000178	78.41	gold quality
vermiform appendix	UBERON:0001154	77.21	gold quality
left ovary	UBERON:0002119	76.46	gold quality
islet of Langerhans	UBERON:0000006	76.06	gold quality
adrenal gland	UBERON:0002369	76.04	gold quality
ovary	UBERON:0000992	75.75	gold quality
right ovary	UBERON:0002118	75.44	gold quality
left adrenal gland cortex	UBERON:0035825	75.22	gold quality
right adrenal gland	UBERON:0001233	75.14	gold quality
gastrocnemius	UBERON:0001388	73.90	gold quality
muscle of leg	UBERON:0001383	73.84	gold quality
left adrenal gland	UBERON:0001234	73.83	gold quality
stomach	UBERON:0000945	73.27	gold quality
liver	UBERON:0002107	72.62	gold quality
kidney	UBERON:0002113	72.46	gold quality
heart	UBERON:0000948	71.71	gold quality
body of pancreas	UBERON:0001150	71.65	gold quality
corpus callosum	UBERON:0002336	71.51	gold quality
calcaneal tendon	UBERON:0003701	71.44	gold quality
endometrium	UBERON:0001295	71.31	gold quality
tibial artery	UBERON:0007610	71.24	gold quality
popliteal artery	UBERON:0002250	71.17	gold quality
heart left ventricle	UBERON:0002084	71.14	gold quality
ascending aorta	UBERON:0001496	70.58	gold quality
lymph node	UBERON:0000029	70.40	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.77

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Alterations of miR571 and miR-652 serum levels in patients with chronic liver disease reflect their putative roles in the mediation of fibrogenic and inflammatory processes in distinct cellular compartments involved in the pathogenesis of liver cirrhosis. (PMID:22412969)
• Five miRNAs were significantly upregulated in type 2 diabetes mellitus patients (p < 0.05) including miR-661, miR-571, miR-770-5p, miR-892b and miR-1303. Moreover, the levels of the five miRNAs were higher in patients with complications than in those without complications. (PMID:26831044)
• we identify miR-571 as the first miRNA that prevents aberrant DNA replication (PMID:31431461)
• MiR-770-5p, miR-661 and miR-571 expression level in serum and tissue samples of foot ulcer caused by diabetes mellitus type II in Iranian population. (PMID:34643918)
• MiR-571 affects the development and progression of liver fibrosis by regulating the Notch3 pathway. (PMID:34750395)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.