MIR572

Summary

MIR572 (microRNA 572, HGNC:32828) is a microRNA gene on chromosome 4p15.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693157 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32828
Approved symbol	MIR572
Name	microRNA 572
Location	4p15.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-572
Ensembl gene	ENSG00000207716
Ensembl biotype	miRNA
Entrez	693157
RNAcentral	URS000075C548 — miRNA, 95 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384983

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384983 — 1 exons

Exon	Start	End
ENSE00001499990	11368827	11368921

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 88.39.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	88.39	gold quality
sural nerve	UBERON:0015488	88.19	gold quality
muscle of leg	UBERON:0001383	78.54	gold quality
gastrocnemius	UBERON:0001388	78.06	gold quality
bone marrow	UBERON:0002371	77.47	gold quality
blood	UBERON:0000178	76.32	gold quality
monocyte	CL:0000576	75.35	gold quality
prefrontal cortex	UBERON:0000451	73.95	gold quality
heart left ventricle	UBERON:0002084	70.43	gold quality
right frontal lobe	UBERON:0002810	70.34	gold quality
right atrium auricular region	UBERON:0006631	70.05	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.01	gold quality
frontal cortex	UBERON:0001870	69.88	gold quality
ascending aorta	UBERON:0001496	69.77	gold quality
stomach	UBERON:0000945	69.76	gold quality
tibial artery	UBERON:0007610	69.34	gold quality
body of stomach	UBERON:0001161	69.08	gold quality
thoracic aorta	UBERON:0001515	68.89	gold quality
thoracic mammary gland	UBERON:0005200	68.62	gold quality
left adrenal gland cortex	UBERON:0035825	68.61	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.60	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	68.52	gold quality
liver	UBERON:0002107	68.42	gold quality
endometrium	UBERON:0001295	67.90	gold quality
fundus of stomach	UBERON:0001160	67.89	gold quality
descending thoracic aorta	UBERON:0002345	67.73	gold quality
anterior cingulate cortex	UBERON:0009835	67.33	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.23	gold quality
left adrenal gland	UBERON:0001234	67.19	gold quality
omental fat pad	UBERON:0010414	67.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.47

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• miR-572 is involved in the development and restoration of POCD and it may serve as a biological marker for early diagnosis of POCD. (PMID:25680004)
• miR-572 post-transcriptionally regulates SOCS1 and p21 and may play an important role in ovarian cancer progression; miR-572 may represent a potential therapeutic target for ovarian cancer therapy. (PMID:25893382)
• MicroRNA-572 is expressed differently in multiple sclerosis patients with different patterns of clinical progression (PMID:25947625)
• The upregulation of miR-572 and miR-663a was consistent in both the SH-SY5Y and SK-N-SH cells. (PMID:27716787)
• MIRN572 was found to regulate NCAM1 expression in an oligodendroglial cell line. (PMID:28332001)
• Study suggests that tumor oncogene miR572 is a potential biomarker for the diagnosis, treatment and prognosis for renal cell carcinoma. (PMID:30132566)
• Our results demonstrated that circADAMTS14 might suppress hepatocellular carcinoma (HCC) progression through regulating miR-572/ RCAN1 as the competing endogenous RNA. (PMID:30317540)
• MicroRNA-572 targets CDH1 to promote metastasis of Wilms’ tumor. (PMID:31114995)
• MiR-572 promotes the development of non-small cell lung cancer by targeting KLF2. (PMID:35587058)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.