MIR5739

Summary

MIR5739 (microRNA 5739, HGNC:49977) is a microRNA gene on chromosome 22q12.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102466081 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49977
Approved symbol	MIR5739
Name	microRNA 5739
Location	22q12.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5739
Ensembl gene	ENSG00000276162
Ensembl biotype	miRNA
Entrez	102466081
RNAcentral	URS000075C41D — ncRNA, 80 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000619803

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000619803 — 1 exons

Exon	Start	End
ENSE00003733998	28459869	28459948

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 97.21.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	97.21	gold quality
kidney	UBERON:0002113	91.30	gold quality
adrenal tissue	UBERON:0018303	88.28	gold quality
calcaneal tendon	UBERON:0003701	86.08	gold quality
skeletal muscle tissue	UBERON:0001134	84.66	gold quality
stomach	UBERON:0000945	83.11	gold quality
muscle of leg	UBERON:0001383	82.48	gold quality
adult mammalian kidney	UBERON:0000082	80.19	gold quality
lung	UBERON:0002048	79.41	gold quality
liver	UBERON:0002107	77.80	gold quality
blood	UBERON:0000178	76.98	gold quality
intestine	UBERON:0000160	76.56	gold quality
endometrium	UBERON:0001295	74.12	gold quality
body of stomach	UBERON:0001161	73.08	gold quality
heart	UBERON:0000948	72.09	gold quality
corpus callosum	UBERON:0002336	71.91	gold quality
monocyte	CL:0000576	71.54	gold quality
colon	UBERON:0001155	71.30	gold quality
ascending aorta	UBERON:0001496	71.12	gold quality
descending thoracic aorta	UBERON:0002345	71.08	gold quality
gastrocnemius	UBERON:0001388	71.07	gold quality
right lobe of thyroid gland	UBERON:0001119	69.00	gold quality
tibial artery	UBERON:0007610	68.79	gold quality
popliteal artery	UBERON:0002250	68.56	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.07	gold quality
left adrenal gland	UBERON:0001234	67.98	gold quality
body of pancreas	UBERON:0001150	67.41	gold quality
Ammon’s horn	UBERON:0001954	66.88	gold quality
right lobe of liver	UBERON:0001114	66.65	gold quality
esophagus mucosa	UBERON:0002469	66.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The hsa-miR-5739 downregulated endothelial cells that were derived from human ES cells significantly suppressed the translational level of endoglin. (PMID:22020071)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.