MIR574

Summary

MIR574 (microRNA 574, HGNC:32830) is a microRNA gene on chromosome 4p14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693159 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32830
Approved symbol	MIR574
Name	microRNA 574
Location	4p14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-574
Ensembl gene	ENSG00000207944
Ensembl biotype	miRNA
OMIM	615469
Entrez	693159
RNAcentral	URS000075BE91 — miRNA, 96 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385209

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385209 — 1 exons

Exon	Start	End
ENSE00001500215	38868032	38868127

Expression profiles

Bgee: expression breadth broad, 73 present calls, max score 96.75.

Top tissues by expression

73 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	96.75	gold quality
calcaneal tendon	UBERON:0003701	83.98	gold quality
bone marrow	UBERON:0002371	78.06	gold quality
blood	UBERON:0000178	76.87	gold quality
right frontal lobe	UBERON:0002810	75.46	gold quality
right lung	UBERON:0002167	74.66	gold quality
liver	UBERON:0002107	73.99	gold quality
left coronary artery	UBERON:0001626	73.86	gold quality
monocyte	CL:0000576	73.81	gold quality
gastrocnemius	UBERON:0001388	72.81	gold quality
body of pancreas	UBERON:0001150	72.40	gold quality
fundus of stomach	UBERON:0001160	71.98	gold quality
stomach	UBERON:0000945	71.67	gold quality
urinary bladder	UBERON:0001255	71.48	gold quality
body of stomach	UBERON:0001161	71.01	gold quality
ascending aorta	UBERON:0001496	70.95	gold quality
thoracic aorta	UBERON:0001515	70.81	gold quality
right lobe of liver	UBERON:0001114	70.60	gold quality
heart	UBERON:0000948	70.53	gold quality
left adrenal gland	UBERON:0001234	70.40	gold quality
left adrenal gland cortex	UBERON:0035825	70.17	gold quality
adrenal gland	UBERON:0002369	70.01	gold quality
right atrium auricular region	UBERON:0006631	69.59	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.48	gold quality
caudate nucleus	UBERON:0001873	69.19	gold quality
Ammon’s horn	UBERON:0001954	69.16	gold quality
heart left ventricle	UBERON:0002084	69.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.15	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.08	gold quality
lung	UBERON:0002048	69.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 40)

• High serum microRNA 574 expression is associated with early-stage non-small cell lung cancer. (PMID:21258252)
• Interference with HDAC1 and miR-574-5p reconstituted CerS1-2 expression and C(18) -ceramide generation in multiple human (PMID:22180294)
• study is shows that serum miR-574-5p is correlated with the death of sepsis patients (PMID:22344312)
• Functional study revealed that cell proliferation, migration and invasion were significantly inhibited in miR-574-3p-transfected gastric cancer SGC7901 cells. (PMID:22683180)
• Upregulation of miR-338-5p is associated with esophageal squamous cell carcinoma. (PMID:23124769)
• MicroRNA-574-5p has a critical role in TLR9 signaling enhanced tumor progression via down-regulating checkpoint suppressor 1 (PMID:23133627)
• regulation of human CBR1 expression by hsa-miR-574-5p and hsa-miR-921 depends upon rs9024 genotype status (PMID:23133646)
• Sox9-regulated miRNA-574-3p inhibits chondrogenic differentiation of mesenchymal stem cells. (PMID:23626837)
• miR-574-3p blood level was downregulated in FXTAS patients. (PMID:23790110)
• High MIRN574 expression is associated with Glioblastoma multiforme. (PMID:24435880)
• Overexpression of miR-574-3p suppressed ERH protein production and delayed cell growth. (PMID:24566139)
• Three promising exosomal microRNA biomarkers were identified, discriminating prostatic neoplasm patients from control: miR375, miR21, and miR574. (PMID:25814440)
• Importantly we report for the first time two new candidate miRNAs (miR-574-3p and miR-660-5p) as promising prognostic markers (PMID:26416693)
• miR-574-5p enhanced tumor invasion and metastasis of small-cell lung carcinoma. (PMID:26587830)
• identified two miRNAs (miR-206 and miR-574-5p) that were significantly up-regulated in CAD patients as compared with healthy controls (P<0.05). (PMID:26685009)
• Low miR574 expression is associated with Polycystic Ovary Syndrome. (PMID:26771704)
• The results demonstrated that cervical cancer tissues had a significantly increased miR-574-5p expression compared with para-carcinoma tissues. (PMID:27049079)
• miR-574-3p was suggested to have a tumor suppressor effect, and thus, to be a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma. (PMID:27565418)
• Transwell and wound-healing assays showed that miR-574-5p promotes the migration and invasion of NSCLC cells. Furthermore, miR-574-5p enhanced the tyrosine phosphorylation of beta-catenin by repressing PTPRU expression in vitro. (PMID:27761023)
• miR-574 and REL interfere with apoptosis in prostate cancer stem cells. (PMID:27779701)
• Silencing of Smad4, but not Smad2 or Smad3, significantly inhibited the TGF-B1-induced miR-574-3p upregulation in gastric tumor cells. (PMID:28042090)
• The signaling PTCSC3-miR-574-5p-SCAI-Wnt/beta-catenin mediated the proliferation and migration of PTC-1 cells, which was vital for the further papillary thyroid carcinoma therapy and prognosis. (PMID:28513866)
• Translation of VEGFA mRNA in myeloid cells is dictated by a bi-directional interaction between miR-574-3p, a CA-rich microRNA, and hnRNP L. In normoxia, miR-574-3p, acting as a decoy, binds cytoplasmic hnRNP L and prevents its binding to the CARE and stimulation of VEGFA mRNA translation, simultaneously permitting miR-297-mediated translational silencing. (PMID:28520992)
• miR574 overexpression is associated with malignant pulmonary nodules. (PMID:28545454)
• results show the oncogenic potential of miRNA 574-3p in prostate cancer progression and metastasis. (PMID:28734841)
• miR-574-3p was identified to potentially regulate PD-L1 expression in chordoma, which inversely correlated with PD-L1. Positive PD-L1 expression on tumor cells was associated with advanced stages and TILs infiltration, whereas decreased miR-574-3p level correlated with higher muscle invasion, more severe tumor necrosis and poor patient survival. (PMID:29051990)
• The relative expression of serum microRNA-574-3p in hepatocellular carcinoma patients was significantly higher than that in cirrhosis patients and healthy controls, and it may be an important biomarker in the auxiliary diagnosis of hepatocellular carcinoma (PMID:29065698)
• MiR-574-5p expression was elevated in the sera and vascular smooth muscle cells of patients with coronary artery disease. (PMID:29091861)
• miR-365-5p and miR-574-5p may be linked to white adipose tissue hypertrophy via effects on EBF1 expression. (PMID:29191698)
• Up-regulation of miR-574 level in MCF-7 cells promoted the cell growth and G0/G1-to-S phase transition but inhibited cell apoptosis. However, knockdown of miR-574 in MCF-7/Adr cells decreased the IC50 and cell growth. (PMID:29565492)
• Linc-ZNF469-3 promotes lung metastasis of TNBC through miR-574-5p-ZEB1 signaling axis. (PMID:29755127)
• Results showed that transfection of each miR-574 alone, led to Sox17, FoxA2 expression that are related to initiation step of hepatic differentiation. However, concurrent ectopic overexpression of miR-106a, miR-574-3p, and miR-451 together can induce umbilical cord derived mesenchymal stem cells differentiation into functionally mature hepatocytes. (PMID:29763649)
• Detection of exosome miRNAs using molecular beacons for diagnosing prostate cancer. (PMID:30033809)
• Study provided a novel mechanism of miR-574 in regulation of epithelial mesenchymal transition (EMT) and cisplatin sensitivity in human gastric cancer (GC) cells by suppressing ZEB1 function. (PMID:30917930)
• Through activating MYCBP and by sponging miR-574-5p. (PMID:31094023)
• miR-574-5p was significantly down-regulated in the Thoracic aortic aneurysm (TAA) tissue compared to the controls, but was up-regulated in serum samples from a separate group of 28 TAA patients compared to 20 controls (p < 0.001). (PMID:31409059)
• MiR-574-3p exerts as a tumor suppressor in ovarian cancer through inhibiting MMP3 expression. (PMID:31486483)
• Data show that miR-574-5p and miR-574-3p, are inversely expressed and play exactly opposite roles in gastric cancer progression. (PMID:31562301)
• LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR-574-5p. (PMID:31587336)
• miR-574-5p plays a pivotal role in human cardiac fibroblasts (HCFs) myofibroblast differentiation (PMID:31672272)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.