MIR575

Summary

MIR575 (microRNA 575, HGNC:32831) is a microRNA gene on chromosome 4q21.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693160 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32831
Approved symbol	MIR575
Name	microRNA 575
Location	4q21.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-575
Ensembl gene	ENSG00000207746
Ensembl biotype	miRNA
Entrez	693160
RNAcentral	URS000064FA6C — miRNA, 94 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385013

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385013 — 1 exons

Exon	Start	End
ENSE00001500020	82753337	82753430

Expression profiles

Bgee: expression breadth broad, 59 present calls, max score 85.81.

Top tissues by expression

59 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	85.81	gold quality
blood	UBERON:0000178	83.16	gold quality
adrenal tissue	UBERON:0018303	80.49	gold quality
monocyte	CL:0000576	78.99	gold quality
liver	UBERON:0002107	78.29	gold quality
stomach	UBERON:0000945	75.42	gold quality
intestine	UBERON:0000160	74.61	gold quality
islet of Langerhans	UBERON:0000006	74.22	gold quality
lung	UBERON:0002048	74.12	gold quality
kidney	UBERON:0002113	71.52	gold quality
Ammon’s horn	UBERON:0001954	70.27	gold quality
left adrenal gland	UBERON:0001234	69.50	gold quality
ectocervix	UBERON:0012249	69.37	gold quality
substantia nigra	UBERON:0002038	68.94	gold quality
left adrenal gland cortex	UBERON:0035825	68.83	gold quality
small intestine Peyer’s patch	UBERON:0003454	68.65	gold quality
body of pancreas	UBERON:0001150	68.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.51	gold quality
upper lobe of left lung	UBERON:0008952	68.32	gold quality
heart	UBERON:0000948	68.14	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.07	gold quality
lower esophagus	UBERON:0013473	68.03	gold quality
nucleus accumbens	UBERON:0001882	68.00	gold quality
colon	UBERON:0001155	67.85	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.63	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.53	gold quality
skin of abdomen	UBERON:0001416	67.18	gold quality
brain	UBERON:0000955	67.02	gold quality
ascending aorta	UBERON:0001496	66.75	gold quality
right frontal lobe	UBERON:0002810	66.45	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Overexpression of Rab5B largely rescued the miR-575-mediated impairment of angiogenesis. (PMID:30333257)
• miRNA-575 serves a pivotal role in gastric cancer as a cancer promoter gene. (PMID:30844657)
• The ERalpha-miR-575-p27 feedback loop regulates tamoxifen sensitivity in ER-positive Breast Cancer. (PMID:32929377)
• Altered Expression of miR-575 in Glioma is Related to Tumor Cell Proliferation, Migration, and Invasion. (PMID:34272655)
• MicroRNA-575 acts as a novel oncogene via targeting multiple signaling pathways in glioblastoma. (PMID:35901926)
• LncRNA RPL34-AS1 suppresses the proliferation, migration and invasion of esophageal squamous cell carcinoma via targeting miR-575/ACAA2 axis. (PMID:36162992)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.