MIR576

Summary

MIR576 (microRNA 576, HGNC:32832) is a microRNA gene on chromosome 4q25.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693161 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32832
Approved symbol	MIR576
Name	microRNA 576
Location	4q25
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-576
Ensembl gene	ENSG00000207988
Ensembl biotype	miRNA
Entrez	693161
RNAcentral	URS000063C5C4 — miRNA, 98 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385253

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385253 — 1 exons

Exon	Start	End
ENSE00001500259	109488698	109488795

Expression profiles

Bgee: expression breadth broad, 84 present calls, max score 84.78.

Top tissues by expression

84 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
olfactory segment of nasal mucosa	UBERON:0005386	84.78	gold quality
adrenal tissue	UBERON:0018303	82.08	gold quality
calcaneal tendon	UBERON:0003701	81.40	gold quality
blood	UBERON:0000178	80.59	gold quality
adult mammalian kidney	UBERON:0000082	79.79	gold quality
bone marrow	UBERON:0002371	79.45	gold quality
kidney	UBERON:0002113	79.01	gold quality
liver	UBERON:0002107	78.08	gold quality
monocyte	CL:0000576	77.59	gold quality
stomach	UBERON:0000945	77.35	gold quality
islet of Langerhans	UBERON:0000006	74.20	gold quality
endometrium	UBERON:0001295	73.91	gold quality
right atrium auricular region	UBERON:0006631	73.47	gold quality
gastrocnemius	UBERON:0001388	72.97	gold quality
body of stomach	UBERON:0001161	72.70	gold quality
putamen	UBERON:0001874	72.64	gold quality
heart	UBERON:0000948	72.04	gold quality
right adrenal gland	UBERON:0001233	71.16	gold quality
body of pancreas	UBERON:0001150	70.82	gold quality
corpus callosum	UBERON:0002336	70.56	gold quality
adrenal gland	UBERON:0002369	70.28	gold quality
urinary bladder	UBERON:0001255	69.82	gold quality
tibial artery	UBERON:0007610	69.80	gold quality
ascending aorta	UBERON:0001496	69.70	gold quality
lung	UBERON:0002048	69.49	gold quality
left coronary artery	UBERON:0001626	69.37	gold quality
thoracic aorta	UBERON:0001515	69.35	gold quality
skin of abdomen	UBERON:0001416	68.84	gold quality
right lobe of liver	UBERON:0001114	68.79	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.64

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 21)

• Data indicate that expression of miR-1260, -26a, -335*, -576-3p, -628-3p and -664 were consistently dysregulated in both whole blood and H1N1 infected cells. (PMID:24116168)
• induction of miR-576-3p by IRF3 triggers a feedback mechanism to reduce interferon expression and set an antiviral response threshold to likely avoid excessive inflammation (PMID:25232931)
• Study identified the down-regulation of miR-576-3p in bladder cancer cell lines and reported that miR-576-3p, as a potential tumor suppressor in bladder cancer cells by targeting CCND1. (PMID:25556372)
• the downregulation of ITGBL1 might result from highly expressed miR-576-5p in non-small cell lung cancer tissues (PMID:26307393)
• data showed expression of miR-576-3p was decreased in bladder cancer tissue compared with matched bladder tissues; low miR-576-3p expression was associated with advanced tumor stage, lymph node metastasis and recurrence; results demonstrated that down expression of miR-576-3p in bladder cancer was associated with an unfavorable prognosis (PMID:28338199)
• Inhibition of host miR-217 or miR-576-3p restricts Oropouche Virus replication, decreasing viral RNA (up to 8.3 fold) and virus titer. (PMID:29813068)
• MicroRNA-548-3p and MicroRNA-576-5p enhance the migration and invasion of esophageal squamous cell carcinoma cells via NRIP1 down-regulation (PMID:29940757)
• The present study confirms that miR5763p is a novel glioblastoma multiforme inhibitor and its inhibition of the migration and proangiogenic capacity of hypoxiainduced glioma cells is mediated by HIF1alpha. (PMID:31017266)
• miR-576, miR-616 and miR-133a-2 are three newly discovered biomarkers of renal cell carcinoma in this study. (PMID:31350524)
• Linc-PINT acted as a tumor suppressor by sponging miR-543 and miR-576-5p in esophageal cancer. (PMID:31464068)
• MicroRNA-576-5p enhances the invasion ability of trophoblast cells in preeclampsia by targeting TFAP2A. (PMID:31701656)
• Results indicate that miR576 was differentially upregulated in triplenegative breast cancer (TNBC) patients with recurrence allowing to distinguish them from those without recurrence. (PMID:31746410)
• miR5763p overexpression enhances cisplatin sensitivity of ovarian cancer cells by dysregulating PDL1 and cyclin D1. (PMID:33236151)
• miR5765p promotes epithelialtomesenchymal transition in colorectal cancer by targeting the Wnt5amediated Wnt/betacatenin signaling pathway. (PMID:33300054)
• LINC01133 hampers the development of gastric cancer through increasing somatostatin via binding to microRNA-576-5p. (PMID:34318683)
• Circular RNA hsa_circ_0012673 Promotes Breast Cancer Progression via miR-576-3p/SOX4 Axis. (PMID:35794450)
• circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p. (PMID:36138395)
• Hsa_circ_0001445 works as a cancer suppressor via miR-576-5p/SFRP1 axis regulation in ovarian cancer. (PMID:36259450)
• miRNA-576-5p promotes endometrial cancer cell growth and metastasis by targeting ZBTB4. (PMID:36538280)
• Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma Progression. (PMID:37625838)
• LINC-PINT suppresses breast cancer cell proliferation and migration via MEIS2/PPP3CC/NF-kappaB pathway by sponging miR-576-5p. (PMID:37660994)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.