MIR577

Summary

MIR577 (microRNA 577, HGNC:32833) is a microRNA gene on chromosome 4q26.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693162 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32833
Approved symbol	MIR577
Name	microRNA 577
Location	4q26
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-577
Ensembl gene	ENSG00000207931
Ensembl biotype	miRNA
Entrez	693162
RNAcentral	URS00006D03D5 — miRNA, 96 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385196

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385196 — 1 exons

Exon	Start	End
ENSE00001500202	114656759	114656854

Expression profiles

Bgee: expression breadth broad, 42 present calls, max score 82.70.

Top tissues by expression

42 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	82.70	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	82.07	gold quality
corpus callosum	UBERON:0002336	82.02	gold quality
heart	UBERON:0000948	79.40	gold quality
kidney	UBERON:0002113	79.32	gold quality
sural nerve	UBERON:0015488	77.37	gold quality
blood	UBERON:0000178	76.30	gold quality
stomach	UBERON:0000945	75.02	gold quality
adult mammalian kidney	UBERON:0000082	73.73	gold quality
monocyte	CL:0000576	72.93	gold quality
body of stomach	UBERON:0001161	72.84	gold quality
intestine	UBERON:0000160	72.32	gold quality
adrenal tissue	UBERON:0018303	72.22	gold quality
calcaneal tendon	UBERON:0003701	70.02	gold quality
right frontal lobe	UBERON:0002810	69.41	gold quality
colon	UBERON:0001155	69.31	gold quality
Ammon’s horn	UBERON:0001954	68.01	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.99	gold quality
body of pancreas	UBERON:0001150	67.93	gold quality
ascending aorta	UBERON:0001496	67.70	gold quality
esophagus mucosa	UBERON:0002469	67.66	gold quality
transverse colon	UBERON:0001157	66.66	gold quality
putamen	UBERON:0001874	66.36	gold quality
skin of leg	UBERON:0001511	65.51	gold quality
amygdala	UBERON:0001876	64.89	gold quality
cerebellar hemisphere	UBERON:0002245	64.40	gold quality
skin of abdomen	UBERON:0001416	64.01	gold quality
tibial nerve	UBERON:0001323	63.92	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.52	gold quality
ectocervix	UBERON:0012249	63.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 16)

• Report role for mir-577/TSGA10 axis in regulation esophageal squamous cell carcinoma progression. (PMID:24294352)
• Study shows that miR-577 is down-regulated in glioblastoma tumors and cell lines and its overexpression directly regulates Wnt signaling by inhibiting expression of b-catenin and LRP6. (PMID:25764520)
• Data suggest that microRNA-577 is down-regulated in colorectal cancer (CRC) tumors and cell lines; however, CRC cells that are resistant to antineoplastic 5-fluorouracil have elevated levels of microRNA-577; thus, miR-577 appears to acts as tumor suppressor in CRC likely through targeting HSP27. (PMID:28150434)
• findings indicate that miR-577 is a potential tumor suppressor in Papillary Thyroid Cancer by targeting SphK2, and may be a potential therapeutic target in PTC. (PMID:28975989)
• WNT2B acted as a target of miR-577, and WNT2B played the oncogenic role in osteosarcoma cells by activating Wnt/beta-catenin pathway. (PMID:29108989)
• Results indicated that miR-577 suppressed EMT by inhibiting Rab25 expression in breast cancer (BC). MiR-577 and Rab25 are considered potential targets of BC treatment. (PMID:29524309)
• the study revealed that lncRNA DANCR might promote the proliferation of osteoarthritis chondrocytes and reduce apoptosis through the miR-577/SphK2 axis. (PMID:29678573)
• Study confirmed that miR577 expression was markedly downregulated in both in hepatocellular carcinoma (HCC) tissues and cell lines and related to malignant clinicopathological features, such as venous invasion and advanced TNM stage. MiR577 was identified as an inhibitor of cell metastatic ability and EMT progress in HCC through direct interaction with HOXA1. (PMID:29693150)
• DANCR promoted HSP27 expression and its mediation of proliferation/metastasis via miR-577 sponging. (PMID:29717105)
• MiR-577 serves an important role in regulating cell proliferation, migration and invasion, and the epithelial-mesenchymal transition process in non-small cell lung cancer cells and miR-577 may have inhibited WNT2B expression at both the mRNA and protein expression levels by directly targeting the 3’UTR of the WNT2B mRNA. (PMID:30015869)
• these results indicated that miR577 may have served tumor suppressive roles in nonsmall cell lung cancer by directly targeting HOXA1 (PMID:30628697)
• Low miR577 expression is associated with invasion in nasopharyngeal carcinoma. (PMID:31344361)
• LncRNA DSCAM-AS1 promotes non-small cell lung cancer progression via regulating miR-577/HMGB1 axis. (PMID:32386483)
• Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression. (PMID:35676608)
• MicroRNA-577/EIF5A2 axis suppressed the proliferation of DDP-resistant nasopharyngeal carcinoma cells by blocking TGF-beta signaling pathway. (PMID:37500510)
• Knocking-down long non-coding RNA LINC01094 prohibits chondrocyte apoptosis via regulating microRNA-577/metal-regulatory transcription factor 1 axis. (PMID:38758016)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.