MIR578

Summary

MIR578 (microRNA 578, HGNC:32834) is a microRNA gene on chromosome 4q32.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 693163 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32834
Approved symbol	MIR578
Name	microRNA 578
Location	4q32.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-578
Ensembl gene	ENSG00000207559
Ensembl biotype	miRNA
Entrez	693163
RNAcentral	URS000064EB09 — miRNA, 96 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000384828

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000384828 — 1 exons

Exon	Start	End
ENSE00001499835	165386242	165386337

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 87.60.

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	87.60	gold quality
adrenal tissue	UBERON:0018303	86.17	gold quality
kidney	UBERON:0002113	77.50	gold quality
islet of Langerhans	UBERON:0000006	76.62	gold quality
stomach	UBERON:0000945	74.56	gold quality
adrenal gland	UBERON:0002369	74.36	gold quality
gastrocnemius	UBERON:0001388	73.80	gold quality
right hemisphere of cerebellum	UBERON:0014890	73.44	gold quality
cerebellar hemisphere	UBERON:0002245	72.66	gold quality
endometrium	UBERON:0001295	72.44	gold quality
left uterine tube	UBERON:0001303	71.47	gold quality
heart left ventricle	UBERON:0002084	71.07	gold quality
body of pancreas	UBERON:0001150	70.53	gold quality
blood	UBERON:0000178	70.45	gold quality
anterior cingulate cortex	UBERON:0009835	70.44	gold quality
left coronary artery	UBERON:0001626	70.43	gold quality
substantia nigra	UBERON:0002038	70.31	gold quality
prostate gland	UBERON:0002367	70.10	gold quality
amygdala	UBERON:0001876	70.02	gold quality
caudate nucleus	UBERON:0001873	69.79	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	69.66	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.55	gold quality
nucleus accumbens	UBERON:0001882	69.36	gold quality
heart	UBERON:0000948	69.30	gold quality
body of stomach	UBERON:0001161	69.18	gold quality
popliteal artery	UBERON:0002250	69.13	gold quality
thoracic aorta	UBERON:0001515	69.10	gold quality
tibial artery	UBERON:0007610	69.01	gold quality
putamen	UBERON:0001874	68.89	gold quality
ascending aorta	UBERON:0001496	68.88	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.66

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 6)

• Our data highlight the role of miR-578 and miR-573 in controlling BRCA 1/2-related angiogenesis in a series of familial breast cancers (PMID:25333258)
• Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks. (PMID:33962616)
• Hsa_circ_0008673 Promotes Breast Cancer Progression by MiR-578/GINS4 Axis. (PMID:36628810)
• CircTNPO1 promotes the tumorigenesis of osteosarcoma by sequestering miR-578 to upregulate WNT5A expression. (PMID:37633479)
• Inhibition of miR-578 through SOCS2-dependent manner reverses gefitinib resistance in NSCLC cells. (PMID:37948135)
• Exosomal circFAM63Bsuppresses bone regeneration of postmenopausal osteoporosis via regulating miR-578/HMGA2 axis. (PMID:38151824)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.