MIR5787

Summary

MIR5787 (microRNA 5787, HGNC:49930) is a microRNA gene on chromosome 3p21.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 102464817 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49930
Approved symbol	MIR5787
Name	microRNA 5787
Location	3p21.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-5787
Ensembl gene	ENSG00000275334
Ensembl biotype	miRNA
Entrez	102464817
RNAcentral	URS000075B8AF — ncRNA, 55 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000611784

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000611784 — 1 exons

Exon	Start	End
ENSE00003718572	50227436	50227490

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 77.54.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left coronary artery	UBERON:0001626	77.54	gold quality
blood	UBERON:0000178	76.42	gold quality
body of stomach	UBERON:0001161	76.11	gold quality
tibial artery	UBERON:0007610	71.89	gold quality
heart left ventricle	UBERON:0002084	71.36	gold quality
right atrium auricular region	UBERON:0006631	70.17	gold quality
gastrocnemius	UBERON:0001388	70.09	gold quality
hypothalamus	UBERON:0001898	70.09	gold quality
right adrenal gland	UBERON:0001233	69.49	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.06	gold quality
substantia nigra	UBERON:0002038	68.92	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.71	gold quality
putamen	UBERON:0001874	68.37	gold quality
endometrium	UBERON:0001295	68.24	gold quality
esophagus mucosa	UBERON:0002469	68.10	gold quality
left adrenal gland	UBERON:0001234	67.88	gold quality
upper lobe of left lung	UBERON:0008952	67.59	gold quality
skin of leg	UBERON:0001511	67.48	gold quality
omental fat pad	UBERON:0010414	66.90	gold quality
skin of abdomen	UBERON:0001416	66.77	gold quality
myometrium	UBERON:0001296	66.72	gold quality
ascending aorta	UBERON:0001496	66.54	gold quality
transverse colon	UBERON:0001157	66.31	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.94	gold quality
right frontal lobe	UBERON:0002810	65.84	gold quality
right lobe of thyroid gland	UBERON:0001119	65.83	gold quality
small intestine Peyer’s patch	UBERON:0003454	65.78	gold quality
left lobe of thyroid gland	UBERON:0001120	65.40	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.35	gold quality
tibial nerve	UBERON:0001323	65.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR-5787 represses cell growth, in part, by targeting eIF5. (PMID:22062548)
• MiR-5787 Attenuates Macrophages-Mediated Inflammation by Targeting TLR4/NF-kappaB in Ischemic Cerebral Infarction. (PMID:33165670)
• Circulating miR-455-3p, miR-5787, and miR-548a-3p as potential noninvasive biomarkers in the diagnosis of acute graft-versus-host disease: a validation study. (PMID:34247256)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.